Hypertrophic neuropathy and multiple sclerosis.

In a 62-year-old man with multiple sclerosis, postmortem examination disclosed clinically unsuspected findings of hypertrophic neuropathy. The brain and spinal cord contained many typical plaques of multiple sclerosis. Most spinal roots were thickened, and microscopic examination showed onion-bulb changes characteristic of hypertrophic neuropathy. This is the eleventh reported case of a sporadic hypertrophic neuropathy in a patient with multiple sclerosis.