Literature DB >> 6684056

In vivo dopamine receptor agonist binding in rat brain: relation with pharmacological effects.

M G Feenstra, H Rollema, T B Mulder, J B De Vries, A S Horn.   

Abstract

The relation between in vivo rat striatal dopamine (DA) receptor binding of N,N-dipropyl-2-amino-5,6-dihydroxytetralin (DiPr-5,6-ADTN) and the dopaminergic effects of this compound was studied. The results indicate that maximal stereotyped biting and gnawing was associated with maximal saturable binding. At doses which maximally decreased striatal acidic DA metabolite concentrations a 25% or less occupation of binding sites was found. It is suggested that total in vivo binding is associated with stereotypy but not with the biochemical effects.

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Year:  1983        PMID： 6684056     DOI： 10.1016/0014-2999(83)90567-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  In vivo receptor binding, neurochemical and functional studies with the dopamine D-1 receptor antagonist SCH23390.

Authors:  S Hjorth; A Carlsson
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

2.  S(-)DP-5,6-ADTN as an in vivo dopamine receptor ligand: relation between displacement by dopamine agonists and their pharmacological effects.

Authors:  H Rollema; M G Feenstra; C J Grol; M H Lewis; L Staples; R B Mailman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-04       Impact factor: 3.000

3.  Differential effects of dopamine D2 and D3 receptor antagonists in regard to dopamine release, in vivo receptor displacement and behaviour.

Authors:  N Waters; L Löfberg; S Haadsma-Svensson; K Svensson; C Sonesson; A Carlsson
Journal:  J Neural Transm Gen Sect       Date:  1994

4.  In vivo displacement by 3-PPP enantiomers of N,N-dipropyl-5,6-ADTN from dopamine receptor-binding sites in rat striatum.

Authors:  A Carlsson; L Löfberg
Journal:  J Neural Transm       Date:  1985       Impact factor: 3.575

5.  In vivo dopamine (DA) receptor binding and behavioural effects of the putative DA autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 in rats with a unilateral nigral 6-OH-DA lesion.

Authors:  M Hajos; S Hjorth; K Svensson; A Carlsson
Journal:  Exp Brain Res       Date:  1988       Impact factor: 1.972

6.  A homologous series of N-alkylated cis-(+)-(1 S, 2 R)-5-methoxy-1-methyl-2-aminotetralins: central dopamine receptor antagonists showing profiles ranging from classical antagonism to selectivity for autoreceptors.

Authors:  K Svensson; A Carlsson; A M Johansson; L E Arvidsson; J L Nilsson
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575
  6 in total

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