Literature DB >> 6683871

X chromosome-linked transmission and expression of retroviral genomes microinjected into mouse zygotes.

C Stewart, K Harbers, D Jähner, R Jaenisch.   

Abstract

A genomic clone consisting of the Moloney leukemia proviral genome with moderately repetitive mouse sequences was microinjected into the pronucleus of a mouse zygote. An animal was derived that carried multiple copies of proviral DNA in a tandem array. No evidence for homologous recombination was obtained. The viral genome was expressed in this animal and was transmitted as a single unit to its offspring. Subsequent breeding studies revealed that the proviral DNA had integrated on an X chromosome.

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Year:  1983        PMID： 6683871     DOI： 10.1126/science.6683871

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

1.  Developmental fate of a human insulin gene in a transgenic mouse.

Authors:  H van der Putten; F Botteri; K Illmensee
Journal:  Mol Gen Genet       Date:  1984

2.  Maternal transmission of retroviral disease: transgenic mice as a rapid test system for evaluating perinatal and transplacental antiretroviral therapy.

Authors:  A H Sharpe; J J Hunter; R M Ruprecht; R Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

3.  Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection.

Authors:  D Jähner; K Haase; R Mulligan; R Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

4.  Introduction of a selectable gene into different animal tissue by a retrovirus recombinant vector.

Authors:  H Stuhlmann; R Cone; R C Mulligan; R Jaenisch
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

5.  Reprogramming of a melanoma genome by nuclear transplantation.

Authors:  Konrad Hochedlinger; Robert Blelloch; Cameron Brennan; Yasuhiro Yamada; Minjung Kim; Lynda Chin; Rudolf Jaenisch
Journal:  Genes Dev       Date:  2004-08-01       Impact factor: 11.361

6.  Endogenous retroviruses lead to the expression of a histocompatibility antigen detectable by skin graft rejection.

Authors:  M P Colombo; R Jaenisch; P J Wettstein
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205
  6 in total

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