| Literature DB >> 6683644 |
M Beer, G Cocconi, G Ceci, M Varini, F Cavalli.
Abstract
Twenty patients with recurrent or metastatic gastric adenocarcinoma and prior chemotherapy were treated with cisplatin, 60-120 mg/m2 as a 6-hr infusion repeated every 3 weeks. There were 4 partial responses in 18 evaluable patients. Seven patients had stable disease. Time to progression ranged from 6 to 28 weeks. Median WBC nadir was 3.2 X 10(3)/mm3 (range, 1.5-7.1) and platelet nadir 120 X 10(3)/mm3 (range, 13-220). A transient increase in serum creatinine was observed in 6 cases, and nausea and vomiting in all. We conclude that this drug is active in stomach cancer and that it warrants further trials in combination chemotherapy.Entities:
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Year: 1983 PMID： 6683644 DOI： 10.1016/0277-5379(83)90003-2
Source DB: PubMed Journal: Eur J Cancer Clin Oncol ISSN： 0277-5379