Literature DB >> 6683366

Parkinson's disease in 65 pairs of twins and in a set of quadruplets.

C D Ward, R C Duvoisin, S E Ince, J D Nutt, R Eldridge, D B Calne.   

Abstract

Among 43 monozygotic (MZ) and 19 dizygotic (DZ) pairs in which an index case had definite Parkinson's disease (PD), only one MZ pair was definitely concordant for PD. When pairs with questionable clinical features were included, 4 of 48 MZ and 1 of 19 DZ pairs were concordant. The frequency of PD in MZ cotwins of index cases with PD was similar to that expected in an unrelated control group matched for age and sex. Although we were unable to identify a single environmental agent, we conclude that the major factors in the etiology of PD are nongenetic.

Entities:  

Mesh：

Year:  1983        PMID： 6683366     DOI： 10.1212/wnl.33.7.815

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  48 in total

Review 1.  The genetic basis of Parkinson's disease.

Authors:  T Foltynie; S Sawcer; C Brayne; R A Barker
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-10       Impact factor: 10.154

Review 2.  Parkinson's disease.

Authors:  C D Marsden
Journal:  Postgrad Med J       Date:  1992-07       Impact factor: 2.401

Review 3.  Current theories on the cause of Parkinson's disease.

Authors:  J W Langston
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-06       Impact factor: 10.154

4.  Dystonia-parkinsonism syndrome (XDP) locus: flanking markers in Xq12-q21.1.

Authors:  K G Kupke; M B Graeber; U Müller
Journal:  Am J Hum Genet       Date:  1992-04       Impact factor: 11.025

5.  Twin pairs discordant for neuropathologically confirmed Lewy body dementia.

Authors:  C Sheei-Meei Wang; J R Burke; D C Steffens; C M Hulette; J C S Breitner; B L Plassman
Journal:  J Neurol Neurosurg Psychiatry       Date:  2009-05       Impact factor: 10.154

6.  Uses and limitations of twin studies.

Authors:  S Bundey
Journal:  J Neurol       Date:  1991-10       Impact factor: 4.849

Review 7.  How far are we in understanding the cause of Parkinson's disease?

Authors:  Y Ben-Shlomo
Journal:  J Neurol Neurosurg Psychiatry       Date:  1996-07       Impact factor: 10.154

8.  A gene for Parkinson's disease?

Authors:  C Hawkes
Journal:  BMJ       Date:  1996-11-23

9.  Genes and parkinsonism.

Authors:  N Wood
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-04       Impact factor: 10.154

Review 10.  Parkinson's disease in 1984: an update.

Authors:  A E Lang; R D Blair
Journal:  Can Med Assoc J       Date:  1984-11-01       Impact factor: 8.262
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