Initial impressions of dazoxiben in the treatment of the ischaemic limb.

1 Dazoxiben, a selective thromboxane synthetase inhibitor, which is active after oral administration, has been used to treat eight patients with severe peripheral vascular disease associated with ischaemic rest pain. 2 Patients were selected for treatment on the basis that amputation was the only alternative procedure. 3 Three of eight patients are well and pain-free 1, 7 and 11 months after initially receiving the drug and have not required amputation. 4 Dazoxiben may prove useful in the treatment of peripheral vascular disease.