Eosinophilic fasciitis: a mast cell disorder?

The rarity of eosinophilic fasciitis has so far prevented systematic investigations. Its etiology is still unknown and its nosographical position to be defined. We report here a further case whose distinctive features were: a gradual onset simultaneous with allergic bronchial asthma; the absence of eosinophils and presence of a high number of degranulating mast cells and Sezary-like cells in the inflamed fascia. The follow-up and a second biopsy suggested that early steroid treatment is advisable in these patients.