Literature DB >> 6680165

The cerebral ischemic cascade.

W K Hass.   

Abstract

The author reviews the major biochemical events that follow in the wake of a significant brain ischemic insult. Evidence is presented that establishes lactic acidosis as a significant accelerant of the ischemic cascade and that proposes that uncontrolled entry of calcium into the vulnerable neuron triggers cell death.

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Year:  1983        PMID： 6680165

Source DB:  PubMed          Journal:  Neurol Clin        ISSN： 0733-8619            Impact factor:   3.806


  4 in total

Review 1.  Preclinical drug evaluation for combination therapy in acute stroke using systematic review, meta-analysis, and subsequent experimental testing.

Authors:  Victoria E O'Collins; Malcolm R Macleod; Susan F Cox; Leena Van Raay; Elena Aleksoska; Geoffrey A Donnan; David W Howells
Journal:  J Cereb Blood Flow Metab       Date:  2010-10-27       Impact factor: 6.200

2.  Influence of cerebral ischemia and post-ischemic reperfusion on mitochondrial oxidative phosphorylation.

Authors:  C K Kurup; K K Kumaroo; A J Dutka
Journal:  J Bioenerg Biomembr       Date:  1990-02       Impact factor: 2.945

3.  Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia.

Authors:  C M Brown; C Calder; C Linton; C Small; B A Kenny; M Spedding; L Patmore
Journal:  Br J Pharmacol       Date:  1995-08       Impact factor: 8.739

Review 4.  Cerebroprotection for Acute Ischemic Stroke: Looking Ahead.

Authors:  Patrick D Lyden
Journal:  Stroke       Date:  2021-07-22       Impact factor: 10.170
  4 in total

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