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Literature DB >> 6679195

Enzymatic synthesis of S-adenosyl-L-methionine from L-methionine and ATP.

Abstract

S-Adenosyl-L-methionine (SAM) has been synthesized on 7-mmol scale from L-methionine and ATP. The ATP was generated in situ from AMP, and the synthesis of SAM was catalyzed by the enzyme ATP:L-methionine S-adenosyltransferase (EC 2.5.1.6). Although substantial effort was required to obtain even small quantities of enzyme, it has good stability once isolated and immobilized. The SAM produced by this procedure contains 89% of the (-) diasterioisomer and 11% of the (+) diasterioisomer.

Entities: Chemical

Mesh：

Substances：

Year: 1983 PMID： 6679195 DOI： 10.1007/bf02779914

Source DB: PubMed Journal: Appl Biochem Biotechnol ISSN： 0273-2289 Impact factor: 2.926

10 in total

1. Methionine adenosyltransferase: kinetic properties of human and rat liver enzymes.

Authors: H H Tallan; P A Cohen
Journal: Biochem Med Date: 1976-12

2. Activation of methionine for transmethylation. III. The methionine-activating enzyme of Bakers' yeast.

Authors: S H MUDD; G L CANTONI
Journal: J Biol Chem Date: 1958-03 Impact factor: 5.157

3. Enzymatic O-methylation of epinephrine and other catechols.

Authors: J AXELROD; R TOMCHICK
Journal: J Biol Chem Date: 1958-09 Impact factor: 5.157

4. Activation of methionine for transmethylation. Purification of the S-adenosylmethionine synthetase of bakers' yeast and its separation into two forms.

Authors: P K Chiang; G L Cantoni
Journal: J Biol Chem Date: 1977-07-10 Impact factor: 5.157

5. Activation of methionine for transmethylation.

Authors: G L CANTONI
Journal: J Biol Chem Date: 1951-04 Impact factor: 5.157

6. Differential activation of rat liver methionine adenosyltransferase isozymes by dimethylsulfoxide.

Authors: J L Hoffman; G L Kunz
Journal: Biochem Biophys Res Commun Date: 1977-08-22 Impact factor: 3.575

7. Kinetic studies of the mechanism of S-adenosylmethionine synthetase from yeast.

Authors: R C Greene
Journal: Biochemistry Date: 1969-06 Impact factor: 3.162

8. Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction. Deductions concerning the conformation of methionine.

Authors: J B Lombardini; A W Coulter; P Talalay
Journal: Mol Pharmacol Date: 1970-09 Impact factor: 4.436

9. S-Adenosylmethionine synthetase from Escherichia coli.

Authors: G D Markham; E W Hafner; C W Tabor; H Tabor
Journal: J Biol Chem Date: 1980-10-10 Impact factor: 5.157

10. Regulatory properties of adenosine triphosphate-L-methionine S-adenosyltransferase of rat liver.

Authors: J B Lombardini; T C Chou; P Talalay
Journal: Biochem J Date: 1973-09 Impact factor: 3.857

10 in total

1. Accumulation of S-adenosyl-L-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23.

Authors: Dong-Jin Kim; Jung-Hyun Huh; Young-Yell Yang; Choong-Min Kang; In-Hyung Lee; Chang-Gu Hyun; Soon-Kwang Hong; Joo-Won Suh
Journal: J Bacteriol Date: 2003-01 Impact factor: 3.490

2. Chemoenzymatic synthesis and utilization of a SAM analog with an isomorphic nucleobase.

Authors: C Vranken; A Fin; P Tufar; J Hofkens; M D Burkart; Y Tor
Journal: Org Biomol Chem Date: 2016-06-06 Impact factor: 3.876

Review 3. Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.

Authors: Christopher T Walsh; Benjamin P Tu; Yi Tang
Journal: Chem Rev Date: 2017-12-22 Impact factor: 60.622

4. Mechanistic Studies of Radical SAM Enzymes: Pyruvate Formate-Lyase Activating Enzyme and Lysine 2,3-Aminomutase Case Studies.

Authors: Amanda S Byer; Elizabeth C McDaniel; Stella Impano; William E Broderick; Joan B Broderick
Journal: Methods Enzymol Date: 2018-07-07 Impact factor: 1.600

5. Hydrogen Peroxide-Based Fluorometric Assay for Real-Time Monitoring of SAM-Dependent Methyltransferases.

Authors: M Kalim Akhtar; Dhanya Vijay; Saima Umbreen; Chris J McLean; Yizhi Cai; Dominic J Campopiano; Gary J Loake
Journal: Front Bioeng Biotechnol Date: 2018-10-18

6. Advances in Nutritional Epigenetics-A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions.

Authors: Lynda Sedley
Journal: Epigenet Insights Date: 2020-12-18

Review 10. Regulation of Skeletal Muscle Plasticity by Protein Arginine Methyltransferases and Their Potential Roles in Neuromuscular Disorders.

Authors: Derek W Stouth; Tiffany L vanLieshout; Nicole Y Shen; Vladimir Ljubicic
Journal: Front Physiol Date: 2017-11-01 Impact factor: 4.566

10 in total

Enzymatic synthesis of S-adenosyl-L-methionine from L-methionine and ATP.

1. Methionine adenosyltransferase: kinetic properties of human and rat liver enzymes.

2. Activation of methionine for transmethylation. III. The methionine-activating enzyme of Bakers' yeast.

3. Enzymatic O-methylation of epinephrine and other catechols.

4. Activation of methionine for transmethylation. Purification of the S-adenosylmethionine synthetase of bakers' yeast and its separation into two forms.

5. Activation of methionine for transmethylation.

6. Differential activation of rat liver methionine adenosyltransferase isozymes by dimethylsulfoxide.

7. Kinetic studies of the mechanism of S-adenosylmethionine synthetase from yeast.

8. Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction. Deductions concerning the conformation of methionine.

9. S-Adenosylmethionine synthetase from Escherichia coli.

10. Regulatory properties of adenosine triphosphate-L-methionine S-adenosyltransferase of rat liver.

1. Accumulation of S-adenosyl-L-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23.

2. Chemoenzymatic synthesis and utilization of a SAM analog with an isomorphic nucleobase.

Review 3. Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.

4. Mechanistic Studies of Radical SAM Enzymes: Pyruvate Formate-Lyase Activating Enzyme and Lysine 2,3-Aminomutase Case Studies.

5. Hydrogen Peroxide-Based Fluorometric Assay for Real-Time Monitoring of SAM-Dependent Methyltransferases.

6. Advances in Nutritional Epigenetics-A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions.

7. Cost-Effective Production of ATP and S-Adenosylmethionine Using Engineered Multidomain Scaffold Proteins.

8. Enhancing the production of S-adenosyl-L-methionine in Pichia pastoris GS115 by metabolic engineering.

Review 9. Methyltransferase-Directed Labeling of Biomolecules and its Applications.

Review 10. Regulation of Skeletal Muscle Plasticity by Protein Arginine Methyltransferases and Their Potential Roles in Neuromuscular Disorders.