Literature DB >> 6678687

Effect of salicylates on lymphocyte blastogenesis in vitro: association with other non-steroid anti-inflammatory drugs.

P Conti, M G Cifone, E Alesse, G Ianni, P U Angeletti.   

Abstract

High concentrations of the non-steroid anti-inflammatory drugs, alone and in association, reduce the blastogenesis of human lymphocytes in vitro. This effect is probably due to the toxicity of these agents and not to the inhibition of prostaglandin (PG) prosuction. Therefore drugs, such as, salicylates and associations of salicylates with other non-steroid anti-inflammatory drugs, which have a weak action on PG-synthesis, also inhibit proliferation of lymphocytes.

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Year:  1983        PMID： 6678687     DOI： 10.1007/bf02032168

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN： 0770-3198            Impact factor:   2.980


  14 in total

1.  Antagonism of the gastrointestinal ulcerogenic effect of some nonsteroidal anti-inflammatory agents by sodium salicylate.

Authors:  E Ezer; E Palosi; G Hajós; L Szporny
Journal:  J Pharm Pharmacol       Date:  1976-08       Impact factor: 3.765

2.  Changes in intracellular prostaglandin content during activation of lymphocytes by phytohaemagglutinin.

Authors:  C A Phillips; E Z Girit; J E Kay
Journal:  FEBS Lett       Date:  1978-10-01       Impact factor: 4.124

3.  Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

Authors:  A Böyum
Journal:  Scand J Clin Lab Invest Suppl       Date:  1968

4.  Activation of lymphocytes by H2O2(1).

Authors:  A Finazzi-Agrò; P Conti; M Hofmann; P U Angeletti; G Rotilio
Journal:  Agents Actions Suppl       Date:  1980

5.  Partial reversal of the cellular immune defect in common variable immunodeficiency with indomethacin.

Authors:  J S Goodwin; A D Bankhurst; S A Murphy; D S Selinger; R P Messner; R C Williams
Journal:  J Clin Lab Immunol       Date:  1978-11

6.  Multiple sites on prostaglandin cyclooxygenase are determinants in the action of nonsteroidal antiinflammatory agents.

Authors:  J L Humes; C A Winter; S J Sadowski; F A Kuehl
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

7.  Effect of prostaglandins on complement receptors of human lymphocytes.

Authors:  D Venza-Teti; A Misefari
Journal:  Adv Prostaglandin Thromboxane Res       Date:  1980

8.  Significance of prostaglandins in the regulation of cyclic events in the ovary and uterus.

Authors:  H R Lindner; U Zor; F Kohen; S Bauminger; A Amsterdam; M Lahav; Y Salomon
Journal:  Adv Prostaglandin Thromboxane Res       Date:  1980

9.  Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal.

Authors:  P Conti; A Continenza
Journal:  J Pathol       Date:  1980-08       Impact factor: 7.996

10.  Interaction of salicylates and other non-steroidal anti-inflammatory agents in rats as shown by gastro-ulcerogenic and anti-inflammatory activities, and plasma concentrations.

Authors:  T Corell; K M Jensen
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1979-09
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  2 in total

1.  Reduced human lymphocyte blastogenesis and enhancement of adenosine triphosphate (ATP) by L-carnitine.

Authors:  P Conti; M Reale; S Stuard; G Spoto; F Picerno; T Ferrara; F C Placido; R C Barbacane; A Albertazzi; B M Errichi
Journal:  Mol Cell Biochem       Date:  1994-02-09       Impact factor: 3.396

2.  Pathogenic Mechanisms and In Vitro Diagnosis of AERD.

Authors:  Dirk Schäfer; Steffen Maune
Journal:  J Allergy (Cairo)       Date:  2012-05-10
  2 in total

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