Literature DB >> 66749

Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944.

N Sakuragawa, M Sakuragaw, T Kuwabara, P G Pentchev, J A Barranger, R O Brady.   

Abstract

Organs of rats treated with the drug A Y-9944 for 5 days showed a significant reduction in sphingomyelinase activity. Evidence is presented which suggests that the reduction is due to impaired enzyme synthesis.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 66749     DOI： 10.1126/science.66749

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  15 in total

1.  Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: implications for an intracellular distribution-based drug interaction.

Authors:  Ryan S Funk; Jeffrey P Krise
Journal:  Mol Pharm       Date:  2012-04-06       Impact factor: 4.939

2.  Predicting coordinated lipid biosynthesis: application to the surfactant-accommodated epidermis.

Authors:  H Y Ando; G G Gazdick; E T Sugita; R L Schnaare
Journal:  Lipids       Date:  1988-11       Impact factor: 1.880

3.  The biochemical and morphological response of hydrolytic enzymes in the developing brain to hypocholesterolemic agents.

Authors:  R B Ramsey; V W Fischer
Journal:  Acta Neuropathol       Date:  1980       Impact factor: 17.088

4.  Niemann-Pick disease. Sphingomyelinosis of Siamese cats.

Authors:  S P Snyder; R S Kingston; D A Wenger
Journal:  Am J Pathol       Date:  1982-08       Impact factor: 4.307

5.  Lysosome lipid storage disorder in NCTR-BALB/c mice. I. Description of the disease and genetics.

Authors:  M D Morris; C Bhuvaneswaran; H Shio; S Fowler
Journal:  Am J Pathol       Date:  1982-08       Impact factor: 4.307

6.  High activity of acid sphingomyelinase in major depression.

Authors:  J Kornhuber; A Medlin; S Bleich; V Jendrossek; A W Henkel; J Wiltfang; E Gulbins
Journal:  J Neural Transm (Vienna)       Date:  2005-11       Impact factor: 3.575

Review 7.  Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network.

Authors:  Jan Skácel; Barbara S Slusher; Takashi Tsukamoto
Journal:  J Med Chem       Date:  2021-01-04       Impact factor: 7.446

8.  Effect of liposomal phospholipid composition on cholesterol transfer between microsomal and liposomal vesicles.

Authors:  C Bhuvaneswaran; K A Mitropoulos
Journal:  Biochem J       Date:  1986-09-15       Impact factor: 3.857

9.  Preparation of radiolabled tetracosa mono- and dienoic acid methyl esters from rat erythrocyte lipids by thin layer chromatography.

Authors:  G A Rao; R L Kilpatrick; S C Goheen; E C Larkin
Journal:  Lipids       Date:  1980-09       Impact factor: 1.880

10.  Retinal degeneration in a rodent model of Smith-Lemli-Opitz syndrome: electrophysiologic, biochemical, and morphologic features.

Authors:  Steven J Fliesler; Neal S Peachey; Michael J Richards; Barbara A Nagel; Dana K Vaughan
Journal:  Arch Ophthalmol       Date:  2004-08
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.