Literature DB >> 667368

Problems in the detection of carriers of hemophilia A: the influence of stress and thrombin.

U Göbel, R von Kries, H Jürgens, H von Voss.   

Abstract

After exposure to stress, factor VIII coagulant activity and factor VIII antigen were determined in healthy volunteers for about 3 days. Three out of four volunteers at different time showed results resembling a carrier state. In vitro incubation of plasma with thrombin in decreasing concentrations showed increased factor VIII coagulant activity, although no fibrin clot or fibrin monomers were formed. The concentration of factor VIII antigen remained constant. The action of thrombin can explain the misclassification of known carriers.

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Year:  1978        PMID： 667368     DOI： 10.1007/BF01006552

Source DB:  PubMed          Journal:  Blut        ISSN： 0006-5242


  24 in total

1.  Detection of carriers of haemophilia: a 'blind' study.

Authors:  C R Rizza; I L Rhymes; D E Austen; P B Kernoff; S A Aroni
Journal:  Br J Haematol       Date:  1975-08       Impact factor: 6.998

2.  Nervous regulation of factor-VIII levels in man.

Authors:  P M Mannucci; Z M Ruggeri; G Gagnatelli
Journal:  Br J Haematol       Date:  1971-02       Impact factor: 6.998

3.  Alterations of fibrinolysis and blood coagulation induced by exercise, and the role of beta-adrenergic-receptor stimulation.

Authors:  R J Cohen; S E Epstein; L S Cohen; L H Dennis
Journal:  Lancet       Date:  1968-12-14       Impact factor: 79.321

4.  [Problems of conductor demonstration in haemophilia A: error possibilities in the determination of factor-VIII-associated antigen].

Authors:  B Salfner; U Göbel; H Kokemohr; H Voss; C Petrich
Journal:  Blut       Date:  1977-04

5.  Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.

Authors:  C B Laurell
Journal:  Anal Biochem       Date:  1966-04       Impact factor: 3.365

6.  Mechanism of plasminogen activator and factor VIII increase after vasoactive drugs.

Authors:  P M Mannucci; M Aberg; I M Nilsson; B Robertson
Journal:  Br J Haematol       Date:  1975-05       Impact factor: 6.998

7.  The generation of fibrinopeptide A in clinical blood samples: evidence for thrombin activity.

Authors:  H L Nossel; M Ti; K L Kaplan; K Spanondis; T Soland; V P Butler
Journal:  J Clin Invest       Date:  1976-11       Impact factor: 14.808

8.  In vivo and in vitro effects of thrombin and plasmin on human factor VIII (AHF).

Authors:  E C Lian; R L Nunez; D R Harkness
Journal:  Am J Hematol       Date:  1976       Impact factor: 10.047

9.  Immunologic differentiation of classic hemophilia (factor 8 deficiency) and von Willebrand's dissase, with observations on combined deficiencies of antihemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against antihemophilic factor.

Authors:  T S Zimmerman; O D Ratnoff; A E Powell
Journal:  J Clin Invest       Date:  1971-01       Impact factor: 14.808

10.  Detection of carriers of classic hemophilia using an immunologic assay for antihemophilic factor (factor 8().

Authors:  T S Zimmerman; O D Ratnoff; A S Littell
Journal:  J Clin Invest       Date:  1971-01       Impact factor: 14.808
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  1 in total

1.  The clinical relevance of factor VIII: C and factor VII R: Ag determination in newborns.

Authors:  R von Kries; H Jürgens; H von Voss; U Göbel
Journal:  Eur J Pediatr       Date:  1981-10       Impact factor: 3.183
  1 in total

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