| Literature DB >> 6673063 |
A F Kilander, G Dotevall, S P Fällström, R E Gillberg, L A Nilsson, A Tarkowski.
Abstract
To evaluate assay of gliadin antibodies of different immunoglobulin classes as a test for detection of coeliac disease, we analysed sera from 36 adult patients and 8 children with coeliac disease, 62 patients with other gastrointestinal diseases, and 124 blood donors with diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA). Depending on the choice of reference levels for gliadin antibodies of the IgA and IgG classes, respectively, we found a diagnostic sensitivity for coeliac disease of 93-86% and a diagnostic specificity of 95-100%. Determination of gliadin antibodies by DIG-ELISA can thus be used as a test for detection of coeliac disease and selection of patients for small-intestinal biopsy.Entities:
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Year: 1983 PMID： 6673063 DOI： 10.3109/00365528309181610
Source DB: PubMed Journal: Scand J Gastroenterol ISSN： 0036-5521 Impact factor: 2.423