The plasma membrane origin of liver-specific protein (LSP).

Liver-specific lipoprotein (LSP) is a potentially important target antigen for autoimmune liver cell injury, but the complexity of LSP "the preparation" has hindered investigation of anti-LSP immune responses. In the present study, rabbit LSP and isolated liver plasma membranes (LPM) were compared using electron microscopy and marker enzyme analysis to determine the subcellular site of origin of LSP. These results suggest that LSP "the preparation" is highly enriched with plasma membrane.