Literature DB >> 6671199

Structural determination of the capsular polysaccharide of Streptococcus pneumoniae type 19A (57).

E Katzenellenbogen, H J Jennings.   

Abstract

The structure of the Pneumococcus type 19A (57) capsular polysaccharide has been reinvestigated by using methylation analysis and n.m.r. spectroscopy. It is composed of residues of 2-acetamido-2-deoxy-D-mannose, D-glucose, L-rhamnose, and phosphate in the molar ratios of 1:1:1:1. The polysaccharide is linear, and is composed of these components in a repeating unit of the following structure. ---- 4)-beta-D-ManpNAc-(1 ---- 4)-alpha-D-Glcp-(1 ---- 3)-alpha-L- Rhap-(1-PO4-) ---- The type 19A polysaccharide (Na+ salt) was depolymerized by heating it in water at 100 degrees, conditions that also hydrolyzed the newly formed phosphoric monoesters.

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Year:  1983        PMID： 6671199     DOI： 10.1016/0008-6215(83)88459-6

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  10 in total

1.  Comparative genetics of capsular polysaccharide biosynthesis in Streptococcus pneumoniae types belonging to serogroup 19.

Authors:  J K Morona; R Morona; J C Paton
Journal:  J Bacteriol       Date:  1999-09       Impact factor: 3.490

2.  A polysaccharide from Streptococcus sanguis 34 that inhibits coaggregation of S. sanguis 34 with Actinomyces viscosus T14V.

Authors:  F C McIntire; L K Crosby; A E Vatter; J O Cisar; M R McNeil; C A Bush; S S Tjoa; P V Fennessey
Journal:  J Bacteriol       Date:  1988-05       Impact factor: 3.490

Review 3.  Immunogenicity and immunochemistry of Streptococcus pneumoniae capsular polysaccharides.

Authors:  J E van Dam; A Fleer; H Snippe
Journal:  Antonie Van Leeuwenhoek       Date:  1990-06       Impact factor: 2.271

4.  Impact of the conjugation method on the immunogenicity of Streptococcus pneumoniae serotype 19F polysaccharide in conjugate vaccines.

Authors:  Jan Poolman; Carl Frasch; Anu Nurkka; Helena Käyhty; Ralph Biemans; Lode Schuerman
Journal:  Clin Vaccine Immunol       Date:  2010-12-01

5.  Polysaccharide Capsule Composition of Pneumococcal Serotype 19A Subtypes Is Unaltered among Subtypes and Independent of the Nutritional Environment.

Authors:  Silvio D Brugger; Lukas J Troxler; Susanne Rüfenacht; Pascal M Frey; Brigitte Morand; Rudolf Geyer; Kathrin Mühlemann; Stefan Höck; Wolfgang Thormann; Julien Furrer; Stephan Christen; Markus Hilty
Journal:  Infect Immun       Date:  2016-10-17       Impact factor: 3.441

6.  Analysis of the 5' portion of the type 19A capsule locus identifies two classes of cpsC, cpsD, and cpsE genes in Streptococcus pneumoniae.

Authors:  J K Morona; R Morona; J C Paton
Journal:  J Bacteriol       Date:  1999-06       Impact factor: 3.490

Review 7.  Pneumococcal Capsules and Their Types: Past, Present, and Future.

Authors:  K Aaron Geno; Gwendolyn L Gilbert; Joon Young Song; Ian C Skovsted; Keith P Klugman; Christopher Jones; Helle B Konradsen; Moon H Nahm
Journal:  Clin Microbiol Rev       Date:  2015-07       Impact factor: 26.132

8.  Effect of culture conditions on the structure of Streptococcus pneumoniae type 19A(57) capsular polysaccharide.

Authors:  C J Lee; B A Fraser; R A Boykins; J P Li
Journal:  Infect Immun       Date:  1987-08       Impact factor: 3.441

9.  Theoretical and NMR-based Conformational Analysis of Phosphodiester-linked Disaccharides.

Authors:  Alexey G Gerbst; Andrei V Nikolaev; Dmitry V Yashunsky; Alexander S Shashkov; Andrey S Dmitrenok; Nikolay E Nifantiev
Journal:  Sci Rep       Date:  2017-08-21       Impact factor: 4.379

10.  Novel polysaccharide-protein conjugates provide an immunogenic 13-valent pneumococcal conjugate vaccine for S. pneumoniae.

Authors:  Allison E B Turner; Jonas E Gerson; Helen Y So; Daniel J Krasznai; Adrienne J St Hilaire; Donald F Gerson
Journal:  Synth Syst Biotechnol       Date:  2017-01-20
  10 in total

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