Literature DB >> 667038

The interaction of bee melittin with lipid bilayer membranes.

C R Dawson, A F Drake, J Helliwell, R C Hider.   

Abstract

The influence of melittin and the related 8-26 peptide on the stability and electrical properties of bilayer lipid membranes is reported. Melittin, unlike the 8-26 peptide, has a dramatic influence on lipid membranes, causing rupture at dilute concentrations. The circular dichroism of melittin demonstrated that under physiological conditions, in water, melittin is in extended conformation, which is enhanced in aqueous ethanol. However in 'membrane-like' conditions it is essentially alpha-helical. Secondary structure predictions were used to locate possible alpha-helical nucleation centres and a model of melittin was built according to these predictions. It is postulated that melittin causes a wedge effect in membranes.

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Year:  1978        PMID： 667038     DOI： 10.1016/0005-2736(78)90131-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  42 in total

1.  Lipid membrane editing with peptide cargo linkers in cells and synthetic nanostructures.

Authors:  Hua Pan; Jacob W Myerson; Olena Ivashyna; Neelesh R Soman; Jon N Marsh; Joshua L Hood; Gregory M Lanza; Paul H Schlesinger; Samuel A Wickline
Journal:  FASEB J       Date:  2010-03-24       Impact factor: 5.191

2.  Interleukin 2 promoter/enhancer controlled expression of a synthetic cecropin-class lytic peptide in transgenic mice and subsequent resistance to Brucella abortus.

Authors:  W A Reed; P H Elzer; F M Enright; J M Jaynes; J D Morrey; K L White
Journal:  Transgenic Res       Date:  1997-09       Impact factor: 2.788

3.  Nature of melittin-phospholipid interaction.

Authors:  S Georghiou; M Thompson; A K Mukhopadhyay
Journal:  Biophys J       Date:  1982-01       Impact factor: 4.033

4.  Melittin modulates keratinocyte function through P2 receptor-dependent ADAM activation.

Authors:  Anselm Sommer; Anja Fries; Isabell Cornelsen; Nancy Speck; Friedrich Koch-Nolte; Gerald Gimpl; Jörg Andrä; Sucharit Bhakdi; Karina Reiss
Journal:  J Biol Chem       Date:  2012-05-21       Impact factor: 5.157

5.  Process of inducing pores in membranes by melittin.

Authors:  Ming-Tao Lee; Tzu-Lin Sun; Wei-Chin Hung; Huey W Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-08-12       Impact factor: 11.205

6.  Electrophysiological and structural aspects in the frontal cortex after the bee (Apis mellifera) venom experimental treatment.

Authors:  Adrian Florea; Constantin Puică; Mihaela Vinţan; Ileana Benga; Constantin Crăciun
Journal:  Cell Mol Neurobiol       Date:  2011-02-26       Impact factor: 5.046

7.  Interaction of bee venom melittin with zwitterionic and negatively charged phospholipid bilayers: a spin-label electron spin resonance study.

Authors:  J H Kleinschmidt; J E Mahaney; D D Thomas; D Marsh
Journal:  Biophys J       Date:  1997-02       Impact factor: 4.033

8.  Solid-state NMR structure determination of melittin in a lipid environment.

Authors:  Y H Lam; S R Wassall; C J Morton; R Smith; F Separovic
Journal:  Biophys J       Date:  2001-11       Impact factor: 4.033

9.  The influence of melittin on the rotation of band 3 protein in the human erythrocyte membrane.

Authors:  M J Dufton; R C Hider; R J Cherry
Journal:  Eur Biophys J       Date:  1984       Impact factor: 1.733

10.  Dynamic structure of vesicle-bound melittin in a variety of lipid chain lengths by solid-state NMR.

Authors:  Shuichi Toraya; Katsuyuki Nishimura; Akira Naito
Journal:  Biophys J       Date:  2004-08-31       Impact factor: 4.033
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