Local installation of small doses of streptokinase for treatment of thrombotic occlusions of long-term access catheters.

Small doses of streptokinase were infused locally into occluded long-term venous access catheters in seven patients with neoplasia who required such access for the administration of chemotherapy and blood products. This technique resulted in prompt resolution of clot in all patients, was easy to perform, and caused no hemorrhagic side effects or coagulation changes.