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Literature DB >> 666750

Effects of chronic hyperinsulinaemia on hepatic enzymes involved in lipogenesis and carbohydrate metabolism in the young rat.

K L McCormick, J A Widness, J B Susa, R Schwartz.

Abstract

Chronic (6 days) hyperinsulinaemia in young rats produced lower blood glucose concentrations and augmented body- and liver-weight gain. The insulin-treated rats had increased hepatic activities of citrate-cleavage enzyme, 'malic' enzyme and high-substrate (6.6 mM-phosphoenolpyruvate) pyruvate kinase, and decreased glucose 6-phosphatase. There were no changes in activities of phosphoenolpyruvate carboxykinase, phosphofructokinase, low-substrate (1.3 mM-phosphoenolpyruvate) pyruvate kinase, glucokinase and hexokinase.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Fatty Acids

Year: 1978 PMID： 666750 PMCID： PMC1185699 DOI： 10.1042/bj1720327

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

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References

18 in total

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Authors: C SHARMA; R MANJESHWAR; S WEINHOUSE
Journal: J Biol Chem Date: 1963-12 Impact factor: 5.157

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Authors: P A SRERE; A BHADURI
Journal: Biochim Biophys Acta Date: 1962-05-21

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Authors: O D Taunton; F B Stifel; H L Greene; R H Herman
Journal: Biochem Biophys Res Commun Date: 1972-09-26 Impact factor: 3.575

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Authors: S V Jakobsson; G Dallner
Journal: Biochim Biophys Acta Date: 1968-10-15

9. Hepatic pyruvate kinase. Regulation by glucagon, cyclic adenosine 3'-5'-monophosphate, and insulin in the perfused rat liver.

Authors: J B Blair; M A Cimbala; J L Foster; R A Morgan
Journal: J Biol Chem Date: 1976-06-25 Impact factor: 5.157

10. Determination of inorganic phosphate in the presence of labile organic phosphates.

Authors: R Parvin; R A Smith
Journal: Anal Biochem Date: 1969-01 Impact factor: 3.365

Effects of chronic hyperinsulinaemia on hepatic enzymes involved in lipogenesis and carbohydrate metabolism in the young rat.

1. EFFECTS OF DIET AND INSULIN ON GLUCOSE-ADENOSINE TRIPHOSPHATE PHOSPHOTRANSFERASES OF RAT LIVER.

2. Incorporation of radioactive citrate into fatty acids.

3. Rapid reciprocal changes of hepatic glycolytic enzymes and fructose-1,6-diphosphatase following glucagon and insulin injection in vivo.

4. Nature of the increase in liver microsomal glucose-6-phosphatase activity during the early stage alloxan-induced diabetes.

5. Regulatory pattern of liver carbohydrate metabolizing enzymes: insulin as inducer of key glycolytic enzymes.

6. Concentration dependent inhibition of hepatic gluconeogenesis by insulin.

7. The role of hormones in glucose repression in rat liver.

8. Effect of acute insulin deprivation on rat liver glucokinase.

9. Hepatic pyruvate kinase. Regulation by glucagon, cyclic adenosine 3'-5'-monophosphate, and insulin in the perfused rat liver.

10. Determination of inorganic phosphate in the presence of labile organic phosphates.