Literature DB >> 666745

A radiochemical assay for glycine N-acyltransferase activity. Some properties of the enzyme in rat and rabbit.

M O James, J R Bend.   

Abstract

We have developed a sensitive radiochemical assay of glycine N-acyltransferase activity, using phenylacetyl-CoA as the acyl donor and glycine as the acceptor. This assay measures formation of the product, phenylacetylglycine, instead of disappearance of the substrate, phenylacetyl-CoA, as did earlier assays. The subcellular location and some properties of the conjugating activity were determined in liver and kidney of the rabbit and the rat. Rabbit lung and intestine were also tested for activity.

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Year:  1978        PMID： 666745      PMCID： PMC1185694          DOI： 10.1042/bj1720285

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  26 in total

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9.  Intestinal drug absorption and metabolism. 3. Glycine conjugation and accumulation of benzoic acid in rat intestinal tissue.

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10.  The synthesis of taurocholic and glycocholic acids by preparations of human liver. I. Distribution of activity between subcellular fractions.

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4.  Perinatal development of, and effect of chemical pretreatment on, glycine N-acyltransferase activities in liver and kidney of rabbit and rat.

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Journal:  Biochem J       Date:  1978-05-15       Impact factor: 3.857
  4 in total

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