Literature DB >> 666738

Effect of different compounds on 1-aspartamido-beta-N-acetylglucosamine amidohydrolase from human liver.

B Dugal.   

Abstract

The effect of varous compounds on 1-aspartamido-beta-N-acetylglucosamine amidohydrolase (aspartylglucosylaminase, EC 3.5.1.26) was studied. N-Acetylcysteine inhibited the nezyme non-competitively (Ki 3.2 mM), whereas 3-hydroxybutanone inhibited competitively (Ki 4.1 mM). Methionine, isoleucine and cystathionine apparently enhanced the enzyme activity. The enzyme had a mol. wt. of 63000 as determined by gel filtration. The present studies differentiate between the aspartylglucosylaminase from human liver and that obtained from various other sources.

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Year:  1978        PMID： 666738      PMCID： PMC1184029          DOI： 10.1042/bj1710799

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  Purification and some properties of 1-aspartamido-beta-N-acetylglucosamine amidohydrolase from human liver.

Authors:  B Dugal; J Stromme
Journal:  Biochem J       Date:  1977-09-01       Impact factor: 3.857

2.  The glycopeptide linkage of ribonuclease B.

Authors:  T H Plummer; A Tarentino; F Maley
Journal:  J Biol Chem       Date:  1968-10-10       Impact factor: 5.157

3.  Distribution of a glycopeptide-degrading enzyme in tissue and cells.

Authors:  T Ohgushi; I Yamashina
Journal:  Biochim Biophys Acta       Date:  1968-03-11

4.  Studies on enzymes acting on glycopeptides.

Authors:  M Makino; T Kojima; T Ohgushi; I Yamashina
Journal:  J Biochem       Date:  1968-02       Impact factor: 3.387

5.  The purification and properties of a beta-aspartyl N-acetylglucosylamine amidohydrolase from hen oviduct.

Authors:  A L Tarentino; F Maley
Journal:  Arch Biochem Biophys       Date:  1969-03       Impact factor: 4.013

6.  Enzymatic cleavage of 2-acetamido-1-(beta'-L-aspartamido)-1,2-dideoxy-beta-D-glucose by human plasma and seminal fluid. Failure to detect the heterozygous state for aspartylglycosaminuria.

Authors:  R J Pollitt; F A Jenner
Journal:  Clin Chim Acta       Date:  1969-09       Impact factor: 3.786

7.  Enzymatic cleavage of glycopeptides.

Authors:  M Makino; T Kojima; I Yamashina
Journal:  Biochem Biophys Res Commun       Date:  1966-09-22       Impact factor: 3.575

8.  Measurement of 1-aspartamido-beta-N-acetylglucosamine amidohydrolase activity in human tissues.

Authors:  B Dugal
Journal:  Biochem J       Date:  1977-04-01       Impact factor: 3.857

9.  Beta-aspartylglucosylamine amido hydrolase of rat liver and kidney.

Authors:  S Mahadevan; A L Tappel
Journal:  J Biol Chem       Date:  1967-10-25       Impact factor: 5.157

10.  Aspartylglucosaminuria: psychomotor retardation masquerading as a mucopolysaccharidosis.

Authors:  J N Isenberg; H L Sharp
Journal:  J Pediatr       Date:  1975-05       Impact factor: 4.406
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  3 in total

1.  Spectrum of mutations in aspartylglucosaminuria.

Authors:  E Ikonen; P Aula; K Grön; O Tollersrud; R Halila; T Manninen; A C Syvänen; L Peltonen
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

2.  Isolation of a human hepatic 60 kDa aspartylglucosaminidase consisting of three non-identical polypeptides.

Authors:  M Baumann; L Peltonen; P Aula; N Kalkkinen
Journal:  Biochem J       Date:  1989-08-15       Impact factor: 3.857

3.  Purification and structure of human liver aspartylglucosaminidase.

Authors:  J W Rip; M B Coulter-Mackie; C A Rupar; B A Gordon
Journal:  Biochem J       Date:  1992-12-15       Impact factor: 3.857
  3 in total

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