Literature DB >> 6667268

Effects of 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate on fatty acid and glucose metabolism in perfused rat hearts determined using iodine-125 16-iodohexadecanoate.

H S Sherratt, S J Gatley, T R DeGrado, C K Ng, J E Holden.   

Abstract

Long-chain fatty acid oxidation by the isolated perfused rat heart was assayed by external counting using [125I]16-iodohexadecanoic acid as substrate after administration of the hypoketonemic and hypoglycemic compound 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate to rats. Glucose metabolism was also assessed by measuring release of tritium from [2-T]glucose. The oxidation of long chain fatty acids was virtually suppressed in hearts from fed or starved rats given 2[5(4-chlorophenyl)pentyl]oxirane-2-carboxylate while glucose utilization was increased 2-2.5 fold.

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Year:  1983        PMID： 6667268     DOI： 10.1016/0006-291x(83)91646-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.

Authors:  M Morillas; J Clotet; B Rubí; D Serra; J Ariño; F G Hegardt; G Asins
Journal:  Biochem J       Date:  2000-10-15       Impact factor: 3.857

2.  Catabolism of 15-(p-iodophenyl)-R,S-beta-methylpentadecanoic acid (BMIPP) by isolated rat hearts.

Authors:  T R DeGrado; J E Holden; S J Gatley
Journal:  Eur J Nucl Med       Date:  1990

3.  Mathematical model of the metabolism of 123I-16-iodo-9-hexadecenoic acid in an isolated rat heart. Validation by comparison with experimental measurements.

Authors:  F Dubois; J C Depresseux; L Bontemps; L Demaison; C Keriel; J P Mathieu; C Pernin; D Marti-Batlle; M Vidal; P Cuchet
Journal:  Eur J Nucl Med       Date:  1986

4.  Comparison of 16-iodohexadecanoic acid (IHDA) and 15-p-iodophenylpentadecanoic acid (IPPA) metabolism and kinetics in the isolated rat heart.

Authors:  T R DeGrado; J E Holden; C K Ng; D M Raffel; S J Gatley
Journal:  Eur J Nucl Med       Date:  1988

5.  Effects of POCA on metabolism and function in the ischemic rat heart.

Authors:  D J Paulson; J J Noonan; K M Ward; H Stanley; A Sherratt; A L Shug
Journal:  Basic Res Cardiol       Date:  1986 Mar-Apr       Impact factor: 17.165

6.  Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation.

Authors:  P B Corr; M H Creer; K A Yamada; J E Saffitz; B E Sobel
Journal:  J Clin Invest       Date:  1989-03       Impact factor: 14.808
  6 in total

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