[Double heterozygote hemoglobin D/B0 thalassemia. Report of 3 cases in a Portuguese family].

The first Portuguese cases of a combination of Hb D and B0 thalassaemia are reported. The structure of the Hb variant was identified as Hb D Los Angeles, Punjab, Chicago, Portugal. The cases reported belong to one family living in the south of the country: a woman and her two sons. Twice, in two different generations, women with a Hb D gene, married men with B0 thalassaemia trait. The hypochromic and microcytic red cell morphology in the propositi have been the first abnormalities for subsequent investigations.