Adherence of mouse macrophages to plastic lens implants--resulting in the formation of a cellular membrane.

An experiment for the study of the adherence of mouse macrophages to lens implants under tissue culture conditions has been developed. Formation of a continuous monolayer of cells on the surface of a plastic implant after 18 hours of incubation is demonstrated when this is exposed to a fluid with a high concentration of macrophages. Fewer macrophages in a thin fluid layer on the surface of a tissue culture dish made of clear plastic under the same conditions also showed adherence in a noncontinuous pattern. Some of these macrophages adherent to the surface of the plastic dish resembled reactive cell types that have previously been seen on lens implants removed from human eyes.