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Literature DB >> 6664260

Hydroxylation of secondary bile acids in the perfused prairie dog liver.

B I Cohen, A K Singhal, J Mongelli, M A Rothschild, C K McSherry, E H Mosbach.

Abstract

Taurolithocholic acid and deoxycholic acid were perfused into isolated prairie dog livers. Taurolithocholic acid was 7 alpha-hydroxylated to form taurochenodeoxycholic acid, whereas deoxycholic acid was conjugated and 7 alpha-hydroxylated to form taurocholic acid. The low concentrations of secondary bile acids observed in prairie dog bile are due, at least in part, to active bile acid 7 alpha-hydroxylase(s) in the liver of these animals.

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Year: 1983 PMID： 6664260 DOI： 10.1007/bf02534573

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

9 in total

1. Early changes in bile composition and gallstone formation induced by a high cholesterol diet in prairie dogs.

Authors: L DenBesten; S Safaie-Shirazi; W E Connor; S Bell
Journal: Gastroenterology Date: 1974-05 Impact factor: 22.682

Review 2. Hydroxylations in biosynthesis and metabolism of bile acids.

Authors: I Björkhem; H Danielsson
Journal: Mol Cell Biochem Date: 1974-09-30 Impact factor: 3.396

3. Hydroxylations of bile acids by reconstituted systems from rat liver microsomes.

Authors: I Björkhem; H Danielsson; K Wikvall
Journal: J Biol Chem Date: 1974-10-25 Impact factor: 5.157

4. Metabolism of taurolithocholic acid in the hamster.

Authors: S Emerman; N B Javitt
Journal: J Biol Chem Date: 1967-02-25 Impact factor: 5.157

5. Metabolism of bile alcohols in the perfused rabbit liver.

Authors: B I Cohen; T Kuramoto; M A Rothschild; E H Mosbach
Journal: J Biol Chem Date: 1976-05-10 Impact factor: 5.157

6. Bile acids LIII. Application of reverse-phase high-pressure liquid chromatography to the analysis of conjugated bile acids in bile samples.

Authors: R Shaw; J A Smith; W H Elliott
Journal: Anal Biochem Date: 1978-06-01 Impact factor: 3.365

7. Interaction of chenodeoxycholic acid and dietary cholesterol in the treatment of cholesterol gallstones.

Authors: J E Doty; L DenBesten; J J Roslyn; H A Pitt; S L Kuchenbecker; V Porter-Fink
Journal: Am J Surg Date: 1982-01 Impact factor: 2.565

8. Biosynthesis of chenodeoxycholic acid: side-chain hydroxylation of 5 beta-cholestane-3 alpha, 7 alpha-diol by subcellular fractions of guinea pig liver.

Authors: N Hoshita; S Shefer; F W Cheng; B Dayal; A K Batta; G S Tint; G Salen; E H Mosbach
Journal: Lipids Date: 1978-12 Impact factor: 1.880

9. Bile acid synthesis in the isolated, perfused rabbit liver.

Authors: E H Mosbach; M A Rothschild; I Bekersky; M Oratz; J Mongelli
Journal: J Clin Invest Date: 1971-08 Impact factor: 14.808

9 in total

6 in total

1. Dietary hyodeoxycholic acid exerts hypolipidemic effects by reducing farnesoid X receptor antagonist bile acids in mouse enterohepatic tissues.

Authors: Shiro Watanabe; Kyosuke Fujita
Journal: Lipids Date: 2014-09-05 Impact factor: 1.880

Review 6. Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades.

Authors: Alan F Hofmann; Lee R Hagey
Journal: J Lipid Res Date: 2014-05-17 Impact factor: 5.922