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Literature DB >> 666352

Ataxia telangiectasia. Evaluation of radiosensitivity in cultured skin fibroblasts as a diagnostic test.

Abstract

The sensitivity to x-ray inactivation of cultured skin fibroblasts from clinically confirmed and suspected cases of ataxia telangiectasia was compared with that of cultures from normal subjects. The results confirm previous observations of an association between ataxia telangiectasia and enhanced in vitro radiosensitivity, and also suggest that clonal survival of x-irradiated cultures of skin fibroblasts is a valuable technique for confirming the diagnosis of the disease.

Entities: Disease

Mesh：

Year: 1978 PMID： 666352 PMCID： PMC1544929 DOI： 10.1136/adc.53.5.386

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

15 in total

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Authors: P N Cunlift; J R Mann; A H Cameron; K D Roberts; H N Ward
Journal: Br J Radiol Date: 1975-05 Impact factor: 3.039

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Authors: E Elmore; M Swift
Journal: J Cell Physiol Date: 1976-11 Impact factor: 6.384

3. Skin fibroblasts from a D-deletion type retinoblastoma patient are abnormally X-ray sensitive.

Authors: R R Weichselbaum; J Nove; J B Little
Journal: Nature Date: 1977-04-21 Impact factor: 49.962

4. Letter: Changes in radiosensitivity during the in vitro growth of diploid human fibroblasts.

Authors: R Cox; W K Masson
Journal: Int J Radiat Biol Relat Stud Phys Chem Med Date: 1974-08

5. Serum-alpha-fetoprotein levels in patients with ataxia-telangiectasia.

Authors: T A Waldmann; K R McIntire
Journal: Lancet Date: 1972-11-25 Impact factor: 79.321

6. Xeroderma pigmentosum: variants with normal DNA repair and normal sensitivity to ultraviolet light.

Authors: J E Cleaver
Journal: J Invest Dermatol Date: 1972-03 Impact factor: 8.551

7. Radiation reaction in ataxia telangiectasia.

Authors: J L Morgan; T M Holcomb; R W Morrissey
Journal: Am J Dis Child Date: 1968-11

Review 8. Ataxia-telangiectasia: some historic, clinical and pathologic observations.

Authors: E Boder
Journal: Birth Defects Orig Artic Ser Date: 1975

9. Letter: Phenotypic manifestations of ataxia-telangiectasia.

Authors: D I Hoar
Journal: Lancet Date: 1975-11-22 Impact factor: 79.321

10. Ataxia telangiectasia. Neoplasia, untoward response to x-irradiation, and tuberous sclerosis.

Authors: S P Gotoff; E Amirmokri; E J Liebner
Journal: Am J Dis Child Date: 1967-12

17 in total

Review 1. Genetic and biochemical studies with ataxia telangiectasia. A review.

Authors: P C Huang; R B Sheridan
Journal: Hum Genet Date: 1981 Impact factor: 4.132

Review 2. [Clinical details and genetics of recessive ataxias].

Authors: C Zühlke; F Kreuz; K Bürk
Journal: Nervenarzt Date: 2011-04 Impact factor: 1.214

Review 3. Radiological imaging in ataxia telangiectasia: a review.

Authors: Ishani Sahama; Kate Sinclair; Kerstin Pannek; Martin Lavin; Stephen Rose
Journal: Cerebellum Date: 2014-08 Impact factor: 3.847

4. A family showing no evidence of linkage between the ataxia telangiectasia gene and chromosome 11q22-23.

Authors: D Hernandez; C M McConville; M Stacey; C G Woods; M M Brown; P Shutt; G Rysiecki; A M Taylor
Journal: J Med Genet Date: 1993-02 Impact factor: 6.318

5. Studies of cellular hypersensitivity to ionising radiation in Friedreich's ataxia.

Authors: S Chamberlain; P D Lewis
Journal: J Neurol Neurosurg Psychiatry Date: 1982-12 Impact factor: 10.154

6. Cranial MRI in ataxia-telangiectasia.

Authors: F Sardanelli; R C Parodi; C Ottonello; P Renzetti; S Saitta; E Lignana; G L Mancardi
Journal: Neuroradiology Date: 1995-01 Impact factor: 2.804

7. Ataxia telangiectasia with generalized skin pigmentation and early death.

Authors: M Tsukahara; M Masuda; K Ohshiro; K Kobayashi; T Kajii; Y Ejima; M S Sasaki
Journal: Eur J Pediatr Date: 1986-04 Impact factor: 3.183

Review 8. Karyotypic progression in human tumors.

Authors: S R Wolman
Journal: Cancer Metastasis Rev Date: 1983 Impact factor: 9.264

Review 9. Epstein-Barr virus (EBV)-specific cell-mediated and humoral immune responses in ataxia-telangectasia patients.

Authors: G Masucci; I Berkel; M G Masucci; I Ernberg; R Szigeti; F Ersoy; O Sanal; O Yegin; G Henle; W Henle
Journal: J Clin Immunol Date: 1984-09 Impact factor: 8.317

10. Heterogeneity of chromosomal breakage levels in epithelial tissue of ataxia-telangiectasia homozygotes and heterozygotes.

Authors: M P Rosin; H D Ochs; R A Gatti; E Boder
Journal: Hum Genet Date: 1989-09 Impact factor: 4.132