Literature DB >> 666309

In vitro evaluation of a semisynthetic derivative of gentamicin B (Sch 21420).

P K Yu, J A Washington.   

Abstract

The activities of Sch 21420 and amikacin were compared in vitro against 448 clinical bacterial isolates and against 82 gentamicin-resistant isolates of gram-negative bacilli. At 1 mug/ml, Sch 21420 was more active than amikacin against most Enterobacteriaceae but less active against Pseudomonas aeruginosa. Activity of these antibiotics against gentamicin-resistant organisms varied according to the species examined.

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Year:  1978        PMID： 666309      PMCID： PMC352351          DOI： 10.1128/AAC.13.5.891

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  4 in total

1.  In vitro activity of Sch 21420, derivative of gentamicin B, compared to that of amikacin.

Authors:  S A Kabins; C Nathan
Journal:  Antimicrob Agents Chemother       Date:  1978-11       Impact factor: 5.191

2.  Comparison of in vitro activity of Sch 21420, a gentamicin B derivative, with those of amikacin, gentamicin, netilmicin, sisomicin, and tobramycin.

Authors:  C Thornsberry; A L Barry; R N Jones; C N Baker; R E Badal; R R Packer
Journal:  Antimicrob Agents Chemother       Date:  1980-08       Impact factor: 5.191

3.  Temporal variation in nephrotoxicity of low doses of isepamicin in rats.

Authors:  Y Yoshiyama; L Grenier; P Gourde; M Simard; L Lin; N J Morin; M G Bergeron; G Labrecque; D Beauchamp
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

4.  Comparative nephrotoxicity of SCH 21420 and amikacin in rats.

Authors:  L I Rankin; F C Luft; M N Yum; R S Sloan; C B Dinwiddie; L L Isaacs
Journal:  Antimicrob Agents Chemother       Date:  1979-10       Impact factor: 5.191
  4 in total

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