Literature DB >> 666307

Inhibition of platelet function by sulbenicillin and its metabolite.

Y Ikeda, M Kikuchi, S Matsuda, K Toyama, M Hasegawa, K Watanabe, Y Ando.   

Abstract

The effect of sulbenicillin and its major metabolite, alpha-sulfobenzylpenicilloic acid, on platelet function was investigated. Sulbenicillin caused inhibition of platelet aggregation and release reaction in the same manner as carbenicillin. alpha-Sulfobenzylpenicilloic acid was found to cause much stronger inhibition of platelet function. The results indicate that the strong inhibitory action of alpha-sulfobenzylpenicilloic acid may also take part in impaired platelet functions following administration of sulbenicillin to humans.

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Year:  1978        PMID： 666307      PMCID： PMC352348          DOI： 10.1128/AAC.13.5.881

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

1.  Aggregation of blood platelets by adenosine diphosphate and its reversal.

Authors:  G V BORN
Journal:  Nature       Date:  1962-06-09       Impact factor: 49.962

2.  Study of the effects of ticarcillin on blood coagulation and platelet function.

Authors:  C H Brown; E A Natelson; M W Bradshaw; P Alfrey C; T W Williams
Journal:  Antimicrob Agents Chemother       Date:  1975-05       Impact factor: 5.191

3.  The hemostatic defect produced by carbenicillin.

Authors:  C H Brown; E A Natelson; W Bradshaw; T W Williams; C P Alfrey
Journal:  N Engl J Med       Date:  1974-08-08       Impact factor: 91.245

4.  Carbenicillin in renal failure.

Authors:  D H Gordon
Journal:  Lancet       Date:  1970-08-22       Impact factor: 79.321

5.  Carbenicillin-induced bleeding disorder.

Authors:  P D McClure; J G Casserly; C Monsier; D Crozier
Journal:  Lancet       Date:  1970-12-19       Impact factor: 79.321

6.  The metabolic fate of -sulphobenzylpenicillin in rats.

Authors:  Y Nakai; Y Shirakawa; T Fujita; Z Suzuoki; T Fugono
Journal:  Xenobiotica       Date:  1972-03       Impact factor: 1.908

7.  Effects of cephalothin and penicillin G on platelet function in vitro.

Authors:  M A Guccione; M A Packham; J F Mustard
Journal:  Br J Haematol       Date:  1977-01       Impact factor: 6.998

8.  The release of nucleotides, 5-hydroxytryptamine and enzymes from human blood platelets during aggregation.

Authors:  D C Mills; I A Robb; G C Roberts
Journal:  J Physiol       Date:  1968-04       Impact factor: 5.182
  8 in total

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