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Literature DB >> 6662364

Presence of mitochondrial-DNA-like sequences in the human nuclear DNA.

T Tsuzuki, H Nomiyama, C Setoyama, S Maeda, K Shimada.

Abstract

Two lambda phage clones carrying contiguous human nuclear DNA sequences with extensive homology to non-contiguous human mitochondrial 16S ribosomal RNA sequences were isolated from a human gene library. The one clone carried mitochondrial-DNA(mtDNA)-like sequences flanked with two kinds of repetitive nuclear DNA sequences and the other carried mtDNA-like sequences, between unique nuclear DNA sequences and repetitive DNA sequences of Alu-family. These results demonstrate that mtDNA-like sequences are present in human nuclear DNA.

Entities: Species

Mesh：

Substances：
DNA, Mitochondrial
DNA

Year: 1983 PMID： 6662364 DOI： 10.1016/0378-1119(83)90226-3

Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688

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Cited

26 in total

1. Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.

Authors: B Göttgens; J G Gilbert; L M Barton; D Grafham; J Rogers; D R Bentley; A R Green
Journal: Genome Res Date: 2001-01 Impact factor: 9.043

2. Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes.

Authors: M Hirano; A Shtilbans; R Mayeux; M M Davidson; S DiMauro; J A Knowles; E A Schon
Journal: Proc Natl Acad Sci U S A Date: 1997-12-23 Impact factor: 11.205

10. Nuclear counterparts of the cytoplasmic mitochondrial 12S rRNA gene: a problem of ancient DNA and molecular phylogenies.

Authors: A C van der Kuyl; C L Kuiken; J T Dekker; W R Perizonius; J Goudsmit
Journal: J Mol Evol Date: 1995-06 Impact factor: 2.395

Presence of mitochondrial-DNA-like sequences in the human nuclear DNA.

1. Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.

2. Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes.

3. Molecular evolution of a portion of the mitochondrial 16S ribosomal gene region in scleractinian corals.

Review 4. Non-coding RNAs: the dark side of nuclear-mitochondrial communication.

5. Molecular structures of mitochondrial-DNA-like sequences in human nuclear DNA.

6. Properties of some monkey DNA sequences obtained by a procedure that enriches for DNA replication origins.

7. The presence of intact mitochondrial DNA in HeLa cell nuclei.

8. Structure of the 5' end region of the human argininosuccinate synthetase gene.

Review 9. Numtogenesis as a mechanism for development of cancer.

10. Nuclear counterparts of the cytoplasmic mitochondrial 12S rRNA gene: a problem of ancient DNA and molecular phylogenies.