Literature DB >> 6662184

Long term treatment with tienilic acid or thiazides: comparison of antihypertensive and metabolic effects.

L A Ferrara, A Siani, P Strazzullo, F Galletti.   

Abstract

A comparison has been made of arterial pressure and major metabolic parameters during long term treatment with tienilic acid and a hydrochlorothiazide-amiloride combination, using a randomized single-blind study without cross-over. A significant fall in systolic and diastolic blood pressure and no change in most biochemical parameters was observed with both drugs. Serum uric acid concentration was decreased during tienilic acid and was slightly increased whilst subjects took the hydrochlorothiazide-amiloride combination; serum potassium was slightly decreased on tienilic acid. No sign of hepatotoxicity was detected.

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Year:  1983        PMID： 6662184     DOI： 10.1007/bf00542531

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  7 in total

1.  beta-blockers or diuretics in hypertension? A six year follow-up of blood pressure and metabolic side effects.

Authors:  G Berglund; O Andersson
Journal:  Lancet       Date:  1981-04-04       Impact factor: 79.321

2.  Deterioration of glucose tolerance in hypertensive patients on prolonged diuretic treatment.

Authors:  P J Lewis; E M Kohner; A Petrie; C T Dollery
Journal:  Lancet       Date:  1976-03-13       Impact factor: 79.321

3.  Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study.

Authors:  A Helgeland; I Hjermann; I Holme; P Leren
Journal:  Am J Med       Date:  1978-01       Impact factor: 4.965

4.  Ticrynafen and hydrochlorothiazide. A double-blind study of antihypertensive properties with an open crossover.

Authors:  S A Miller; V Vertes
Journal:  JAMA       Date:  1979-05-18       Impact factor: 56.272

5.  A double-blind comparison of the effects of hydrochlorothiazide and tienylic acid (a diuretic with uricosuric properties) in hypertension.

Authors:  A H Gillies; T O Morgan
Journal:  Br J Clin Pharmacol       Date:  1978-10       Impact factor: 4.335

6.  Elevation of serum lipid levels during diuretic therapy of hypertension.

Authors:  R P Ames; P Hill
Journal:  Am J Med       Date:  1976-11       Impact factor: 4.965

7.  Ticrynafen, a uricosuric antihypertensive diuretic.

Authors:  R M Stote; J W Dubb; R G Familiar; F Alexander
Journal:  Clin Pharmacol Ther       Date:  1978-04       Impact factor: 6.875
  7 in total

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