Axo-axonic synapses in the rat striatum.

In the rat striatum axo-axonic synapses are seen relatively rarely in individual sections. From topological data it is concluded that the real occurrence of these synapses is much higher than the apparent occurrence as judged from single sections. A mathematical consideration is given to account for the distance between the two synapses in series. Their possible role in the action of neuroleptic drugs and for the theory of schizophrenia has been postulated.