Literature DB >> 6661504

Cytotoxicity of cyclodepsipeptides on murine lymphocytes and on L 1210 leukemia cells.

E Morel, M Pais, M Turpin, M Guyot.   

Abstract

By in vitro experiments we have demonstrated an important cytotoxic effect of destruxins A, A2, B, B1 and E on L 1210 leukemia cells. This cytotoxic effect was measured by DNA synthesis. The cytotoxic effect on normal mouse spleen lymphocytes was also evaluated. For the most cytotoxic compound, destruxin E, 16 mg/kg was found to be the minimal dose necessary to kill all mice.

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Year:  1983        PMID： 6661504

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN： 0753-3322            Impact factor:   6.529


  5 in total

Review 1.  Recent Advances in Alternaria Phytotoxins: A Review of Their Occurrence, Structure, Bioactivity, and Biosynthesis.

Authors:  He Wang; Yanjing Guo; Zhi Luo; Liwen Gao; Rui Li; Yaxin Zhang; Hazem M Kalaji; Sheng Qiang; Shiguo Chen
Journal:  J Fungi (Basel)       Date:  2022-02-09

2.  Destruxins: fungal-derived cyclohexadepsipeptides with multifaceted anticancer and antiangiogenic activities.

Authors:  R Dornetshuber-Fleiss; P Heffeter; T Mohr; P Hazemi; K Kryeziu; C Seger; W Berger; R Lemmens-Gruber
Journal:  Biochem Pharmacol       Date:  2013-06-06       Impact factor: 5.858

3.  Destruxin B Isolated from Entomopathogenic Fungus Metarhizium anisopliae Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in Human Nonsmall Cell Lung Cancer Cells.

Authors:  Chun-Chi Wu; Tzu-Hsiu Chen; Bing-Lan Liu; Li-Chen Wu; Yung-Ching Chen; Yew-Min Tzeng; Shih-Lan Hsu
Journal:  Evid Based Complement Alternat Med       Date:  2013-09-24       Impact factor: 2.629

4.  Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins.

Authors:  Daniela Heilos; Clemens Röhrl; Christine Pirker; Bernhard Englinger; Dina Baier; Thomas Mohr; Michaela Schwaiger; Shahid Muhammad Iqbal; Sushilla van Schoonhoven; Kristaps Klavins; Tanja Eberhart; Ursula Windberger; Judith Taibon; Sonja Sturm; Hermann Stuppner; Gunda Koellensperger; Rita Dornetshuber-Fleiss; Walter Jäger; Rosa Lemmens-Gruber; Walter Berger
Journal:  Oncotarget       Date:  2018-05-22

5.  Selective apoptotic cell death effects of oral cancer cells treated with destruxin B.

Authors:  Rosa Huang Liu; Shih-Pin Chen; Tsong-Ming Lu; Wei-Yu Tsai; Chung-Hung Tsai; Chi-Chiang Yang; Yew-Min Tzeng
Journal:  BMC Complement Altern Med       Date:  2014-06-28       Impact factor: 3.659
  5 in total

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