Literature DB >> 6661241

Evidence for the metabolic formation of a vicinal dihydrodiol-epoxide from the potent mutagen 1-nitrobenzo(A)pyrene.

M W Chou, P P Fu.   

Abstract

Metabolism of 1-nitrobenzo(a)pyrene (1-nitro-BaP) by rat liver microsomes yielded 1-nitro-BaP trans-7,8-dihydrodiol, 1-nitro-BaP trans-9,10-dihydrodiol and 1-nitro-BaP 7,8,9,10-tetrahydrotetrol. Formation of these metabolites suggests that a vicinal 7,8,9,10-dihydrodiol-epoxide is a metabolite of 1-nitro-BaP.

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Year:  1983        PMID： 6661241     DOI： 10.1016/0006-291x(83)91234-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  2 in total

1.  Guinea-pig liver testosterone 17 beta-dehydrogenase (NADP+) and aldehyde reductase exhibit benzene dihydrodiol dehydrogenase activity.

Authors:  A Hara; M Hayashibara; T Nakayama; K Hasebe; S Usui; H Sawada
Journal:  Biochem J       Date:  1985-01-01       Impact factor: 3.857

Review 2.  DNA adducts and carcinogenicity of nitro-polycyclic aromatic hydrocarbons.

Authors:  P P Fu; D Herreno-Saenz; L S Von Tungeln; J O Lay; Y S Wu; J S Lai; F E Evans
Journal:  Environ Health Perspect       Date:  1994-10       Impact factor: 9.031
  2 in total

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