Literature DB >> 6661236

Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetin.

M Gschwendt, F Horn, W Kittstein, F Marks.   

Abstract

The flavonoid quercetin is a potent inhibitor of calcium- and phospholipid-dependent protein kinase (Ca, PL-PK) activity from mouse brain. Half-maximal inhibition of the kinase occurs at about 10 microM. If the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) is used instead of calcium as a stimulating factor of the kinase enzyme activity is still inhibited by quercetin. The kinase inhibitor, however, does not interfere with the binding of TPA to its receptor.

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Year:  1983        PMID： 6661236     DOI： 10.1016/0006-291x(83)91220-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

1.  Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation.

Authors:  Sina Henrichs; Bangjun Wang; Yoichiro Fukao; Jinsheng Zhu; Laurence Charrier; Aurélien Bailly; Sophie C Oehring; Miriam Linnert; Matthias Weiwad; Anne Endler; Paolo Nanni; Stephan Pollmann; Stefano Mancuso; Alexander Schulz; Markus Geisler
Journal:  EMBO J       Date:  2012-05-01       Impact factor: 11.598

2.  The effect of azelastine and some other antiasthmatic and antiallergic drugs on calmodulin and protein kinase C.

Authors:  E Middleton; P Ferriola; G Drzewiecki; R D Sofia
Journal:  Agents Actions       Date:  1989-08

3.  Effect of flavonoids on tumor promoter-induced basophil histamine release and protein kinase C.

Authors:  E Middleton; P Ferriola; G Drzewiecki
Journal:  Trans Am Clin Climatol Assoc       Date:  1989

4.  Effects of silybin on histamine release from human basophil leucocytes.

Authors:  A Miadonna; A Tedeschi; E Leggieri; M Lorini; M Froldi; C Zanussi
Journal:  Br J Clin Pharmacol       Date:  1987-12       Impact factor: 4.335

Review 5.  Wine as a biological fluid: history, production, and role in disease prevention.

Authors:  G J Soleas; E P Diamandis; D M Goldberg
Journal:  J Clin Lab Anal       Date:  1997       Impact factor: 2.352

6.  Involvement of K+ channels in the quercetin-induced inhibition of neuroblastoma cell growth.

Authors:  B Rouzaire-Dubois; V Gérard; J M Dubois
Journal:  Pflugers Arch       Date:  1993-05       Impact factor: 3.657

7.  Protective role of quercetin on PCBs-induced oxidative stress and apoptosis in hippocampus of adult rats.

Authors:  Kandaswamy Selvakumar; Senthamilselvan Bavithra; Muralidharan Suganthi; Chellakan Selvanesan Benson; Perumal Elumalai; Ramachandran Arunkumar; Gunasekaran Krishnamoorthy; Prabhu Venkataraman; Jagadeesan Arunakaran
Journal:  Neurochem Res       Date:  2011-11-30       Impact factor: 3.996

8.  Variation in expression and protein localization of the PIN family of auxin efflux facilitator proteins in flavonoid mutants with altered auxin transport in Arabidopsis thaliana.

Authors:  Wendy Ann Peer; Anindita Bandyopadhyay; Joshua J Blakeslee; Srinivas N Makam; Rujin J Chen; Patrick H Masson; Angus S Murphy
Journal:  Plant Cell       Date:  2004-06-18       Impact factor: 11.277

9.  Calyculin A induces contractile ring-like apparatus formation and condensation of chromosomes in unfertilized sea urchin eggs.

Authors:  H Tosuji; I Mabuchi; N Fusetani; T Nakazawa
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

10.  Mechanism of quercetin-induced suppression and delay of heat shock gene expression and thermotolerance development in HT-29 cells.

Authors:  Y J Lee; G Erdos; Z Z Hou; S H Kim; J H Kim; J M Cho; P M Corry
Journal:  Mol Cell Biochem       Date:  1994-08-31       Impact factor: 3.396
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