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Literature DB >> 6661199

Age-related changes in albumin elimination in female WAG/Rij rats.

G J Horbach, S H Yap, C F van Bezooijen.

Abstract

Albumin elimination rates were determined in 3-, 12-, 24- and 36-month-old female WAG/Rij rats. No change in elimination half-life was found with age. However, as there was an increase in the whole-body albumin pool, a concomitant increase in albumin clearance was observed at between 12 and 36 months of age. It was concluded that the increase in clearance between 12 and 24 months of age was only due to a change in the animal's physiology, whereas between 24 and 36 months of age it was also due to changes in the albumin molecule. The age-related changes in albumin clearance were thought not to be caused by changes in the albumin excretion via the urine or via the gastrointestinal tract.

Entities: Disease Species

Mesh：

Substances：
Albumins
Serum Albumin

Year: 1983 PMID： 6661199 PMCID： PMC1152506 DOI： 10.1042/bj2160309

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

12 in total

1. Labelling of plasma proteins with radioactive iodine.

Authors: A S MCFARLANE
Journal: Biochem J Date: 1956-01 Impact factor: 3.857

2. I-131-labeling of proteins by the iodine monochloride method.

Authors: R W Helmkamp; M A Contreras; W F Bale
Journal: Int J Appl Radiat Isot Date: 1967-11

3. Rat serum protein changes with age.

Authors: K Salatka; D Kresge; L Harris; D Edelstein; P Ove
Journal: Exp Gerontol Date: 1971-02-01 Impact factor: 4.032

4. Catabolic half-lives of immunoglobulin and albumin as a function of age in mice.

Authors: R P Quinn; G B Price; J M Ellis; T Makinodan
Journal: J Gerontol Date: 1973-07

5. Synthesis and degradation of liver proteins in young and old rats.

Authors: P Ove; M Obenrader; A Lansing
Journal: Biochim Biophys Acta Date: 1972-08-16

6. Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors: G Mancini; A O Carbonara; J F Heremans
Journal: Immunochemistry Date: 1965-09

7. Albumin synthesis by liver parenchymal cells isolated from young, adult and old rats.

Authors: C F van Bezooijen; T Grell; D L Knook
Journal: Biochem Biophys Res Commun Date: 1976-07-26 Impact factor: 3.575

8. Demonstration of protein-losing gastroenteropathy. The quantitative estimation of gastrointestinal protein loss, using 51Cr-labelled plasma proteins.

Authors: J H van Tongeren; W J Reichert
Journal: Clin Chim Acta Date: 1966-07 Impact factor: 3.786

Age-related changes in albumin elimination in female WAG/Rij rats.

1. Labelling of plasma proteins with radioactive iodine.

2. I-131-labeling of proteins by the iodine monochloride method.

3. Rat serum protein changes with age.

4. Catabolic half-lives of immunoglobulin and albumin as a function of age in mice.

5. Synthesis and degradation of liver proteins in young and old rats.

6. Immunochemical quantitation of antigens by single radial immunodiffusion.

7. Albumin synthesis by liver parenchymal cells isolated from young, adult and old rats.

8. Demonstration of protein-losing gastroenteropathy. The quantitative estimation of gastrointestinal protein loss, using 51Cr-labelled plasma proteins.

9. Current experience using the laboratory rat in aging studies.

10. Proteinuria in rats in relation to age-dependent renal changes.

Review 1. Detection of metabolic changes in hepatocytes by quantitative cytochemistry.

2. D-penicillamine metabolism: the role of transformation in blood plasma.

3. Naphthol-yellow-S protein content of individual rat hepatocytes as related to food intake and short-term starvation.