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Literature DB >> 6661158

T-2 toxin effect on isolated perfused rat hearts.

R Yarom, R More, S Raz, Y Shimoni, O Sarel, B Yagen.

Abstract

T-2 toxin is the major lethal component of several Fusarium fungi implicated in the disease of man and animals. We used isolated rats hearts to test the T-2 toxin cardiotoxicity. Electrodynamics and ultrastructural parameters were studied. The main changes consisted of decreased contractility and electrocardiographic abnormalities without much effect on heart rate or QRS and QT intervals. Ultrastructurally, swelling of myofibers and their mitochondria occurred and damage to the plasma membrane was seen. It is possible that the T-2 effect is mediated through soluble thiol to cause cytoplasmic calcium decrease and loss of plasma membrane integrity.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Sesquiterpenes
T-2 Toxin

Year: 1983 PMID： 6661158 DOI： 10.1007/bf01907209

Source DB: PubMed Journal: Basic Res Cardiol ISSN： 0300-8428 Impact factor: 17.165

17 in total

1. Cardiovascular lesions and various tumors found in rats given T-2 toxin, a trichothecene metabolite of Fusarium.

Authors: R Schoental; A Z Joffe; B Yagen
Journal: Cancer Res Date: 1979-06 Impact factor: 12.701

2. Lesions induced in rodents by extracts from cultures of Fusarium poae and F. sporotrichioides.

Authors: R Schoental; A Z Joffe
Journal: J Pathol Date: 1974-01 Impact factor: 7.996

3. The role of T-2 toxin in experimental alimentary toxic aleukia: a toxicity study in cats.

Authors: I Lutsky; N Mor; B Yagen; A Z Joffe
Journal: Toxicol Appl Pharmacol Date: 1978-01 Impact factor: 4.219

4. Effects of feeding T-2 toxin to rats and monkeys.

Authors: C Rukmini; J S Prasad; K Rao
Journal: Food Cosmet Toxicol Date: 1980-06

5. Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis.

Authors: S A Jewell; G Bellomo; H Thor; S Orrenius; M Smith
Journal: Science Date: 1982-09-24 Impact factor: 47.728

6. Blood pressure changes and cardiovascular lesions found in rats given T-2 toxin, a trichothecene secondary metabolite of certain Fusarium microfungi.

Authors: C A Wilson; D M Everard; R Schoental
Journal: Toxicol Lett Date: 1982-01 Impact factor: 4.372

7. Screeing of toxic isolates of Fusarium poae and Fusarium sporotrichiodes involved in causing alimentary toxic aleukia.

Authors: B Yagen; A Z Joffe
Journal: Appl Environ Microbiol Date: 1976-09 Impact factor: 4.792

T-2 toxin effect on isolated perfused rat hearts.

1. Cardiovascular lesions and various tumors found in rats given T-2 toxin, a trichothecene metabolite of Fusarium.

2. Lesions induced in rodents by extracts from cultures of Fusarium poae and F. sporotrichioides.

3. The role of T-2 toxin in experimental alimentary toxic aleukia: a toxicity study in cats.

4. Effects of feeding T-2 toxin to rats and monkeys.

5. Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis.

6. Blood pressure changes and cardiovascular lesions found in rats given T-2 toxin, a trichothecene secondary metabolite of certain Fusarium microfungi.

7. Screeing of toxic isolates of Fusarium poae and Fusarium sporotrichiodes involved in causing alimentary toxic aleukia.

8. The effect of verapamil on the calcium paradox.

9. Lipid peroxidation as a mechanism of injury in cardiac myocytes.

10. The effect of dimethylsulfoxide on the calcium paradox.

1. Effect of T-2 toxin on brain biogenic monoamines in rats and chickens.