Literature DB >> 6660863

Pharmacokinetics of metronidazole in patients undergoing peritoneal dialysis.

J G Cassey, D A Clark, P Merrick, B Jones.   

Abstract

After a single 500-mg intravenous dose of metronidazole, plasma and dialysate levels were measured over a 7.5-h period in five patients undergoing peritoneal dialysis for terminal renal failure. Approximately 10% of this dose was removed by dialysis during that period, and therapeutic levels were maintained in plasma. No routine adjustment in the dosage of metronidazole appears necessary in patients undergoing peritoneal dialysis.

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Year:  1983        PMID: 6660863      PMCID: PMC185414          DOI: 10.1128/AAC.24.6.950

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  3 in total

1.  Susceptibility of anaerobic bacteria to metronidazole, ornidazole, and tinidazole and routine susceptibility testing by standardized methods.

Authors:  J Wust
Journal:  Antimicrob Agents Chemother       Date:  1977-04       Impact factor: 5.191

2.  Use of high-pressure liquid chromatography to determine plasma levels of metronidazole and metabolites after intravenous administration.

Authors:  L A Wheeler; M De Meo; M Halula; L George; P Heseltine
Journal:  Antimicrob Agents Chemother       Date:  1978-02       Impact factor: 5.191

3.  Concentration of metronidazole in serum during peritoneal dialysis.

Authors:  E Holten; N Smith-Erichsen
Journal:  Chemotherapy       Date:  1981       Impact factor: 2.544

  3 in total
  4 in total

1.  Penetration of clindamycin and metronidazole into the appendix and peritoneal fluid in children.

Authors:  H Nagar; S A Berger; B Hammar; A Gorea
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

Review 2.  Drug therapy in patients undergoing peritoneal dialysis. Clinical pharmacokinetic considerations.

Authors:  T W Paton; W R Cornish; M A Manuel; B G Hardy
Journal:  Clin Pharmacokinet       Date:  1985 Sep-Oct       Impact factor: 6.447

Review 3.  Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials.

Authors:  K C Lamp; C D Freeman; N E Klutman; M K Lacy
Journal:  Clin Pharmacokinet       Date:  1999-05       Impact factor: 6.447

Review 4.  Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives.

Authors:  A H Lau; N P Lam; S C Piscitelli; L Wilkes; L H Danziger
Journal:  Clin Pharmacokinet       Date:  1992-11       Impact factor: 6.447

  4 in total

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