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Literature DB >> 6660193

The flow-past chamber: an improved nose-only exposure system for rodents.

Abstract

We have designed a nose-only inhalation exposure chamber in which fresh aerosol is flowed past each exposure port and exhaled air is immediately exhausted. This allows all animals in the chamber to be exposed to the same aerosol concentration. In tests comparing initial lung burdens (ILB) of animals exposed in a standard chamber with those of animals exposed in the flow-past chamber, coefficients of variation in ILBs were significantly smaller for the latter.

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Year: 1983 PMID： 6660193 DOI： 10.1080/15298668391405959

Source DB: PubMed Journal: Am Ind Hyg Assoc J ISSN： 0002-8894

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Cited

14 in total

1. Exposing animals to oxidant gases: nose only vs. whole body.

Authors: Yung Sung Cheng; Larry Bowen; Roy J Rando; Edward M Postlethwait; Giuseppe L Squadrito; Sadis Matalon
Journal: Proc Am Thorac Soc Date: 2010-07

2. Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures.

Authors: Lung-Chi Chen; Morton Lippmann
Journal: Curr Protoc Toxicol Date: 2015-02-02

3. Pharmacokinetics of detirelix following intratracheal instillation and aerosol inhalation in the unanesthetized awake sheep.

Authors: H Schreier; K J McNicol; D B Bennett; Z Teitelbaum; H Derendorf
Journal: Pharm Res Date: 1994-07 Impact factor: 4.200

4. Characterization and application of a nose-only exposure chamber for inhalation delivery of liposomal drugs and nucleic acids to mice.

Authors: G Mainelis; S Seshadri; O B Garbuzenko; T Han; Z Wang; T Minko
Journal: J Aerosol Med Pulm Drug Deliv Date: 2013-03-26 Impact factor: 2.849

The flow-past chamber: an improved nose-only exposure system for rodents.

1. Exposing animals to oxidant gases: nose only vs. whole body.

2. Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures.

3. Pharmacokinetics of detirelix following intratracheal instillation and aerosol inhalation in the unanesthetized awake sheep.

4. Characterization and application of a nose-only exposure chamber for inhalation delivery of liposomal drugs and nucleic acids to mice.

5. Inhalation Exposure to Carbon Nanotubes (CNT) and Carbon Nanofibers (CNF): Methodology and Dosimetry.

6. Characterization of a nose-only inhaled phosgene acute lung injury mouse model.

Review 7. Molecular and cellular mechanism of lung injuries due to exposure to sulfur mustard: a review.

8. First Steps Towards an Understanding of a Mode ofCarcinogenic Action for Vanadium Pentoxide.

9. A biopersistence study following exposure to chrysotile asbestos alone or in combination with fine particles.

10. An experimental approach to the evaluation of the biopersistence of respirable synthetic fibers and minerals.