| Literature DB >> 6659222 |
R M Levin, D R Staskin, A J Wein.
Abstract
The anticholinergic and musculotropic relaxant properties of desmethylimipramine (DMI) on smooth muscle were investigated utilizing cholinergic radioligand receptor binding and in-vitro muscle bath techniques. Receptor binding studies revealed the direct antimuscarinic potency of DMI to be 1/480th that of atropine. Muscle bath studies characterized discrete antimuscarinic and musculotropic actions. An initial, competitive antimuscarinic action could be separated from a delayed onset, noncompetitive musculotropic action by altering the time between the addition of DMI and the addition of bethanechol to the smooth muscle bath.Entities:
Mesh：
Substances：
Year: 1983 PMID： 6659222 DOI： 10.1007/BF00256342
Source DB: PubMed Journal: Urol Res ISSN： 0300-5623