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Literature DB >> 6659210

Experimental induction of crystalluria in rats using mini-osmotic pumps.

Abstract

Crystalluria was induced in male Sprague-Dawley rats by implanting potassium-oxalate-containing mini-osmotic pumps. Urine of all experimental animals had abundant crystals of calcium oxalate, hydroxypatite, struvite, and calcium phosphate. These crystals were similar in morphology to the crystals found in human crystalluria. Histological examination of kidneys and tissue samples from other organs revealed no abnormality. One group of animals was injected with sodium oxalate in addition to implantation of potassium-oxalate-containing mini-osmotic pumps. Bladder urine from these animals contained calcium oxalate microstones and their kidneys had deposits of calcium oxalate crystals.

Entities: Chemical Species

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Year: 1983 PMID： 6659210 DOI： 10.1007/BF00272279

Source DB: PubMed Journal: Urol Res ISSN： 0300-5623

14 in total

1. Crystaloptical and spectroscopical findings with calcium oxalate crystals in the urine sediment: a contribution to the genesis of oxalate stones.

Authors: W Berg; J D Schnapp; H J Schneider; A Hesse; E Hienzsch
Journal: Eur Urol Date: 1976 Impact factor: 20.096

10. Crystallization studies in a urothelial-lined living test tube (the catheterized female rat bladder). I. Calcium oxalate crystal adhesion to the chemically injured rat bladder.

Authors: W B Gill; K Ruggiero; F H Straus
Journal: Invest Urol Date: 1979-11

6 in total

1. Mineralogical signatures of stone formation mechanisms.

Authors: Laurie B Gower; Fairland F Amos; Saeed R Khan
Journal: Urol Res Date: 2010-07-13

2. Crystal-matrix relationships in experimentally induced urinary calcium oxalate monohydrate crystals, an ultrastructural study.

Authors: S R Khan; R L Hackett
Journal: Calcif Tissue Int Date: 1987-09 Impact factor: 4.333

Experimental induction of crystalluria in rats using mini-osmotic pumps.

1. Crystaloptical and spectroscopical findings with calcium oxalate crystals in the urine sediment: a contribution to the genesis of oxalate stones.

2. Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro.

3. Calcium oxalate crystalluria and inhibitors of crystallization in recurrent renal stone-formers.

4. Calcium oxalate crystalluria and urine saturation in recurrent renal stone-formers.

Review 5. Urolithiasis update: biophysical and radiologic advances enhance antistone therapy.

6. Histologic study of the early events in oxalate induced intranephronic calculosis.

7. Urinary crystals and their relation to stone formation.

8. Calcium oxalate crystalluria.

9. Crystalluria in normal subjects and in stone formers with and without thiazide and cellulose phosphate treatment.

10. Crystallization studies in a urothelial-lined living test tube (the catheterized female rat bladder). I. Calcium oxalate crystal adhesion to the chemically injured rat bladder.

1. Mineralogical signatures of stone formation mechanisms.

2. Crystal-matrix relationships in experimentally induced urinary calcium oxalate monohydrate crystals, an ultrastructural study.

Review 3. Experimental models of renal calcium stones in rodents.

Review 4. Nephrocalcinosis in animal models with and without stones.

5. Relationship between experimentally induced crystalluria and relative supersaturation of various stone salts in rats.

6. Continuous infusion of oxalate by minipumps induces calcium oxalate nephrocalcinosis.