Literature DB >> 6658878

Long-acting contraceptive agents: norethisterone esters of arylcarboxylic acids.

A S Wan, T L Ngiam, S L Leung, M L Go, P W Heng, P N Natarajan, A Shafiee, M Vossoghi, F Savabi, C G Francisco.   

Abstract

The synthesis of esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxy-estr-4-en-3-one) with acids containing a benzene ring is described, two methods of esterification being compared in terms of yield and convenience. The activities of these esters as long-acting contraceptive agents have been evaluated.

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Keywords:  Contraception; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Contraceptive Agents--analysis; Examinations And Diagnoses; Family Planning; Laboratory Examinations And Diagnoses; Laboratory Procedures; Norethindrone--analysis; Reproductive Control Agents

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Year:  1983        PMID: 6658878     DOI: 10.1016/0039-128x(83)90101-0

Source DB:  PubMed          Journal:  Steroids        ISSN: 0039-128X            Impact factor:   2.668


  1 in total

1.  Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4-a]pyrazin-3-ones critical for Neuropeptide S antagonist activity.

Authors:  Yanan Zhang; Brian P Gilmour; Hernán A Navarro; Scott P Runyon
Journal:  Bioorg Med Chem Lett       Date:  2008-06-12       Impact factor: 2.823

  1 in total

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