Early effects of high-dosed absorbable amoscanate on rat brain.

An oily suspension of the absorbable form of amoscanate was administered to young adult albino rats in single or repeated oral doses of 25, 125 and 500 mg/kg. At least 3 consecutive doses of 125 or 500 mg/kg were needed to induce a brain lesion. The early change consisted of necrosis of the ependyma of the lateral ventricles, indicating that intoxication may have occurred via the cerebrospinal fluid.