Literature DB >> 6658007

Constriction of fetal ductus arteriosus by non-steroidal anti-inflammatory drugs.

K Momma, H Takeuchi.   

Abstract

Transplacental effects of 24 non-steroidal anti-inflammatory drugs (NSAIDs) on the fetal ductus arteriosus were studied in full-term pregnant rats using the whole-body freezing technique. All sixteen acidic NSAIDs constricted the fetal ductus in a dose-dependent relationship, but considerable differences in the intensity of effect was noticed with the clinical dose of each drug. Six of the eight basic NSAIDs did not constrict the fetal ductus at 50 to 100 times the usual clinical dose. It is concluded that acidic NSAIDs probably should not be administered to pregnant women. However, it may be established in the future that some basic NSAIDs can be administered safely to pregnant women without hazardous effect on the fetus.

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Year:  1983        PMID： 6658007     DOI： 10.1016/0090-6980(83)90200-9

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  13 in total

1.  Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data.

Authors:  Shingo Tanaka; Takeshi Kanagawa; Kazuo Momma; Satoko Hori; Hiroki Satoh; Takeshi Nagamatsu; Tomoyuki Fujii; Tadashi Kimura; Yasufumi Sawada
Journal:  Br J Clin Pharmacol       Date:  2017-07-27       Impact factor: 4.335

Review 2.  Rheumatoid arthritis and pregnancy: safety considerations in pharmacological management.

Authors:  Ashima Makol; Kerry Wright; Shreyasee Amin
Journal:  Drugs       Date:  2011-10-22       Impact factor: 9.546

Review 3.  Use of DMARDs and biologics during pregnancy and lactation in rheumatoid arthritis: what the rheumatologist needs to know.

Authors:  Megan L Krause; Shreyasee Amin; Ashima Makol
Journal:  Ther Adv Musculoskelet Dis       Date:  2014-10       Impact factor: 5.346

4.  PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth.

Authors:  Artiom Gruzdev; MyTrang Nguyen; Martina Kovarova; Beverly H Koller
Journal:  Prostaglandins Other Lipid Mediat       Date:  2012-02-11       Impact factor: 3.072

5.  Prediction and evaluation of fetal toxicity induced by NSAIDs using transplacental kinetic parameters obtained from human placental perfusion studies.

Authors:  Kyohei Shintaku; Satoko Hori; Hiroki Satoh; Kiyomi Tsukimori; Hitoo Nakano; Tomoyuki Fujii; Yuji Taketani; Hisakazu Ohtani; Yasufumi Sawada
Journal:  Br J Clin Pharmacol       Date:  2012-02       Impact factor: 4.335

Review 6.  Treatment of inflammatory rheumatic disorders in pregnancy: what are the safest treatment options?

Authors:  M Ostensen; R Ramsey-Goldman
Journal:  Drug Saf       Date:  1998-11       Impact factor: 5.606

7.  Increased cardiac workload by closure of the ductus arteriosus leads to hypertrophy and apoptosis rather than to hyperplasia in the late fetal period.

Authors:  Maurice J B van den Hoff; Ronald H Lekanne Deprez; Jan M Ruijter; Piet A J de Boer; Sabina Tesink-Taekema; Anita A Buffing; Wouter H Lamers; Antoon F M Moorman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-08-31       Impact factor: 3.000

8.  Evidence against the hypothesis that prostaglandins are the vasodepressor agents of pregnancy. Serial studies in chronically instrumented, conscious rats.

Authors:  K P Conrad; M C Colpoys
Journal:  J Clin Invest       Date:  1986-01       Impact factor: 14.808

Review 9.  Management of RA medications in pregnant patients.

Authors:  Monika Østensen; Frauke Förger
Journal:  Nat Rev Rheumatol       Date:  2009-06-09       Impact factor: 20.543

10.  Shingles in Pregnancy: An Elusive Case of Left Upper Quadrant Abdominal Pain.

Authors:  Jennifer Wh Wong; Jennifer My Chin; Ryan J Schlueter
Journal:  Hawaii J Med Public Health       Date:  2018-08
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