Literature DB >> 6654957

Brain tumor growth and response to chemotherapy in the subrenal capsule assay.

M Weizsäcker, A Nagamune, K Rathmer, W Wechsler.   

Abstract

Pieces from eight freshly biopsied human gliomas and tumors grown from a human glioma (U118MG) established by transplantation and a rat glioma (RG2) were transplanted under the renal capsule of normal, immunocompetent rats. The effects of chemotherapy administered intraperitoneally to host rats were evaluated by measuring the growth of implanted tumor specimens. Results could be obtained within 7 days of transplantation and suggest that the subrenal capsule assay might be useful in the future for the rapid evaluation of the sensitivity of human brain tumors to therapeutic manipulation. The limitations of the assay are discussed.

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Year:  1983        PMID： 6654957     DOI： 10.1007/BF00402613

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  11 in total

1.  Human brain tumor transplantation into nude mice.

Authors:  W R Shapiro; G A Basler; N L Chernik; J B Posner
Journal:  J Natl Cancer Inst       Date:  1979-03       Impact factor: 13.506

2.  Determinants for the establishment of permanent tissue culture lines from human gliomas.

Authors:  B Westermark; J Pontén; R Hugosson
Journal:  Acta Pathol Microbiol Scand A       Date:  1973-11

3.  Development of a clonogenic cell assay for human brain tumors.

Authors:  M L Rosenblum; D A Vasquez; T Hoshino; C B Wilson
Journal:  Cancer       Date:  1978-06       Impact factor: 6.860

4.  Potentials and possible pitfalls of human stem cell analysis.

Authors:  M L Rosenblum; D V Dougherty; C Reese; C B Wilson
Journal:  Cancer Chemother Pharmacol       Date:  1981       Impact factor: 3.333

5.  Heterotransplantation of human cancers into nude mice: a model system for human cancer chemotherapy.

Authors:  B C Giovanella; J S Stehlin; L J Williams; S S Lee; R C Shepard
Journal:  Cancer       Date:  1978-11       Impact factor: 6.860

6.  Quantitation of differential sensitivity of human-tumor stem cells to anticancer drugs.

Authors:  S E Salmon; A W Hamburger; B Soehnlen; B G Durie; D S Alberts; T E Moon
Journal:  N Engl J Med       Date:  1978-06-15       Impact factor: 91.245

7.  Growth of human tumor xenografts implanted under the renal capsule of normal immunocompetent mice.

Authors:  A E Bogden; P M Haskell; D J LePage; D E Kelton; W R Cobb; H J Esber
Journal:  Exp Cell Biol       Date:  1979

8.  Chemotherapy responsiveness of human tumors as first transplant generation xenografts in the normal mouse: six-day subrenal capsule assay.

Authors:  A E Bogden; W R Cobb; D J Lepage; P M Haskell; T A Gulkin; A Ward; D E Kelton; H J Esber
Journal:  Cancer       Date:  1981-07-01       Impact factor: 6.860

9.  Radiation and drug response of the rat glioma RG2.

Authors:  M Weizsäcker; A Nagamune; R Winkelströter; H Vieten; W Wechsler
Journal:  Eur J Cancer Clin Oncol       Date:  1982-09

10.  Human tumour xenografts established and serially transplanted in mice immunologically deprived by thymectomy, cytosine arabinoside and whole-body irradiation.

Authors:  P J Selby; J M Thomas; P Monaghan; J Sloane; M J Peckham
Journal:  Br J Cancer       Date:  1980-01       Impact factor: 7.640
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  1 in total

1.  Current brain tumour models with particular consideration of the transplantation techniques. Outline of literature and personal preliminary results.

Authors:  B Rama; O Spoerri; M Holzgraefe; H D Mennel
Journal:  Acta Neurochir (Wien)       Date:  1986       Impact factor: 2.216
  1 in total

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