Literature DB >> 6654753

The effect of testicular x-irradiation on spermatogenesis in man. A comparison with the mouse.

D K Clifton, W J Bremner.   

Abstract

Existing data concerning the effects of x-irradiation on spermatogenesis in man were analyzed and the results were compared to published data on the mouse. Testicular x-irradiation produced a transient, but substantial, suppression of sperm counts in man, with an ED50 near 11 rad. The length of time to recovery was proportional to the irradiation dose. The ED50 for suppression of type A spermatogonia following radiation exposure in man was similar (9.7 rad), although the response curves for spermatogonia and sperm count were matogonia in the mouse was parallel to that found in man, but with an ED 50 of 30.0 rad. These results suggest that, compared to the mouse, spermatogenesis in man is approximately 3.1 times more sensitive to ionizing irradiation.

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Mesh：

Year:  1983        PMID： 6654753     DOI： 10.1002/j.1939-4640.1983.tb00765.x

Source DB:  PubMed          Journal:  J Androl        ISSN： 0196-3635


  29 in total

1.  Differences in radiation sensitivity of recovery of spermatogenesis between rat strains.

Authors:  Mahmoud Abuelhija; Connie C Weng; Gunapala Shetty; Marvin L Meistrich
Journal:  Toxicol Sci       Date:  2012-01-23       Impact factor: 4.849

Review 2.  Effects of chemotherapy and radiotherapy on spermatogenesis in humans.

Authors:  Marvin L Meistrich
Journal:  Fertil Steril       Date:  2013-09-04       Impact factor: 7.329

3.  Induction of sperm head abnormalities by incorporated radionuclides: dependence on subcellular distribution, type of radiation, dose rate, and presence of radioprotectors.

Authors:  D V Rao; V R Narra; R W Howell; V K Lanka; K S Sastry
Journal:  Radiat Res       Date:  1991-01       Impact factor: 2.841

Review 4.  Beyond the mouse monopoly: studying the male germ line in domestic animal models.

Authors:  Raquel González; Ina Dobrinski
Journal:  ILAR J       Date:  2015

Review 5.  Long-term complications of therapeutic exposures in childhood: lessons learned from childhood cancer survivors.

Authors:  Smita Bhatia
Journal:  Pediatrics       Date:  2012-11-19       Impact factor: 7.124

6.  Rat models of post-irradiation recovery of spermatogenesis: interstrain differences.

Authors:  M Abuelhija; C C Weng; G Shetty; M L Meistrich
Journal:  Andrology       Date:  2012-11-29       Impact factor: 3.842

7.  Relationship between spermatogonial stem cell survival and testis function after cytotoxic therapy.

Authors:  M L Meistrich
Journal:  Br J Cancer Suppl       Date:  1986

8.  Comparison of different adjuvant radiotherapy approaches in childhood bladder/prostate rhabdomyosarcoma treated with conservative surgery.

Authors:  Frank Heinzelmann; Daniela Thorwarth; Ulf Lamprecht; Theodor W Kaulich; Jörg Fuchs; Guido Seitz; Martin Ebinger; Rupert Handgretinger; Michael Bamberg; Martin Weinmann
Journal:  Strahlenther Onkol       Date:  2011-10-29       Impact factor: 3.621

Review 9.  Cryptorchidism after the Fukushima Daiichi Nuclear Power Plant accident:causation or coincidence?

Authors:  Yoshiyuki Kojima; Susumu Yokoya; Noriaki Kurita; Takayuki Idaka; Tetsuo Ishikawa; Hideaki Tanaka; Yoshiko Ezawa; Hitoshi Ohto
Journal:  Fukushima J Med Sci       Date:  2019

10.  Leydig cells contribute to the inhibition of spermatogonial differentiation after irradiation of the rat.

Authors:  G Shetty; W Zhou; C C Y Weng; S H Shao; M L Meistrich
Journal:  Andrology       Date:  2016-03-18       Impact factor: 3.842
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