Literature DB >> 6654389

Induction of IgE-isotype specific tolerance by passive antigenic stimulation of the respiratory mucosa.

J D Sedgwick, P G Holt.   

Abstract

Repeated exposure of high IgE-responder BN rats to an aerosol of ovalbumin (OVA) induced tolerance which was specific both for the antigen and the IgE antibody class. Radiotracer studies with 125I-OVA indicated that inhaled antigen doses in the low microgram range were tolerogenic, the bulk of the inhaled antigen being distributed 2:1 between the gastro-intestinal and respiratory tracts. Subsequent gastric intubation studies showed that the gastric component did not contribute to tolerance induction, suggesting that antigenic stimulation of the respiratory mucosa was central to this process.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6654389      PMCID： PMC1454368     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  14 in total

1.  In vivo responses to inhaled proteins. I. Quantitative analysis of antigen uptake, fate, and immunogenicity in a rabbit model system.

Authors:  J B Willoughby; W F Willoughby
Journal:  J Immunol       Date:  1977-12       Impact factor: 5.422

2.  Synthesis of rat IgE by aerosol immunization.

Authors:  C A Van Hout; H G Johnson
Journal:  J Immunol       Date:  1972-03       Impact factor: 5.422

3.  Production of homocytotropic antibody in guinea pigs inhalated with an extract of the house dust mite, Dermatophagoides farinae.

Authors:  A Ishii; T Matsuhashi; J Miyamoto; M Sasa
Journal:  Jpn J Exp Med       Date:  1973-02

4.  The induction of tolerance to a soluble protein antigen by oral administration.

Authors:  H C Thomas; M V Parrott
Journal:  Immunology       Date:  1974-10       Impact factor: 7.397

5.  The toxicity of inactivated bacteria and endotoxin in mice suffering from protein malnutrition.

Authors:  P Price; R G Bell
Journal:  J Reticuloendothel Soc       Date:  1975-10

6.  An investigation of the allergens of Ascaris lumbricoides using a radioallergosorbent test (RAST) and sera of naturally infected humans: comparison with an allergen for mice identified by a passive cutaneous anaphylaxis test.

Authors:  I J O'Donnell; G F Mitchell
Journal:  Aust J Biol Sci       Date:  1978-10

7.  The respiratory response in sensitized rats to aerosol challenge.

Authors:  F Carswell; J Oliver
Journal:  Immunology       Date:  1978-03       Impact factor: 7.397

8.  Inhibition of specific immune responses by feeding protein antigens. IV. Evidence for tolerance and specific active suppression of cell-mediated immune responses to ovalbumin.

Authors:  S D Miller; D G Hanson
Journal:  J Immunol       Date:  1979-11       Impact factor: 5.422

9.  Activation of IgE regulatory mechanisms by transmucosal absorption of antigen.

Authors:  E E Jarrett
Journal:  Lancet       Date:  1977-07-30       Impact factor: 79.321

10.  The respiratory response of sensitized rats to challenge with antigen aerosols.

Authors:  H Piechuta; M E Smith; N N Share; G Holme
Journal:  Immunology       Date:  1979-10       Impact factor: 7.397
View more
  15 in total

1.  The distribution of IgE plasma cells in lymphoid and non-lymphoid tissues of high-IgE responder rats: differential localization of antigen-specific and 'bystander' components of the IgE response to inhaled antigen.

Authors:  C McMenamin; B Girn; P G Holt
Journal:  Immunology       Date:  1992-12       Impact factor: 7.397

2.  Down-regulation of immune responses to inhaled antigen: studies on the mechanism of induced suppression.

Authors:  J D Sedgwick; P G Holt
Journal:  Immunology       Date:  1985-12       Impact factor: 7.397

3.  Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uveoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens.

Authors:  A D Dick; Y F Cheng; A McKinnon; J Liversidge; J V Forrester
Journal:  Br J Ophthalmol       Date:  1993-03       Impact factor: 4.638

4.  Suppression of autologous peripheral blood mononuclear cell proliferation by alveolar macrophages from young infants.

Authors:  H J Bunn; C R A Hewitt; J Grigg
Journal:  Clin Exp Immunol       Date:  2002-05       Impact factor: 4.330

5.  Splenic regulation of the murine pulmonary lymph node response.

Authors:  E M Allen; P Abramoff; J N Fink; N J Calvanico
Journal:  Clin Exp Immunol       Date:  1987-08       Impact factor: 4.330

6.  Suppression of IgE responses by antigen inhalation: studies on the role of genetic and environmental factors.

Authors:  P G Holt; D Britten; J D Sedgwick
Journal:  Immunology       Date:  1987-01       Impact factor: 7.397

7.  Immunoreactivity for interleukin 3 and 5 and granulocyte/macrophage colony-stimulating factor of intestinal mucosa in bronchial asthma.

Authors:  B Wallaert; P Desreumaux; M C Copin; I Tillie; A Benard; J F Colombel; B Gosselin; A B Tonnel; A Janin
Journal:  J Exp Med       Date:  1995-12-01       Impact factor: 14.307

8.  Intranasal administration of retinal antigens suppresses retinal antigen-induced experimental autoimmune uveoretinitis.

Authors:  A D Dick; Y F Cheng; J Liversidge; J V Forrester
Journal:  Immunology       Date:  1994-08       Impact factor: 7.397

9.  Extracellular Matrix Protein Mindin is Required for the Complete Allergic Response to Fungal-Associated Proteinase.

Authors:  Robert M Tighe; Erin N Potts; Feifei Feng; Zhuowei Li; Benjamin Frush; You-Wen He; David B Corry; Paul W Noble; John W Hollingsworth
Journal:  J Allergy Ther       Date:  2011-09-20

Review 10.  Innate immune control of pulmonary dendritic cell trafficking.

Authors:  Donald N Cook; Kim Bottomly
Journal:  Proc Am Thorac Soc       Date:  2007-07
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.