Literature DB >> 665436

The neutrophil adherence assay as a method for detecting unique anti-inflammatory agents.

V J Stecher, G L Chinea.   

Abstract

Neutrophil adhesiveness is an important component of the pathophysiology of the inflammatory process. Modulation of this function could result in a reduction in the degree of inflammation and connective tissue damage. A simple technique using filtration of whole blood through nylon fiber columns has been developed to study the effect of anti-inflammatory agents on the adherence of rat peripheral blood neutrophils. Gold and chloroquine, in addition to many standard anti-inflammatory drugs, have been shown to cause inhibition of neutrophil adherence. Measurement of this parameter of cell behavior has the potential of detecting anti-inflammatory agents not normally effective in the standard animal models.

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Year:  1978        PMID： 665436     DOI： 10.1007/BF01966612

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  7 in total

1.  The effect of anti-inflammatory agents and inflammation on granulocyte adherence. Evidence for regulation by plasma factors.

Authors:  R R MacGregor
Journal:  Am J Med       Date:  1976-11       Impact factor: 4.965

2.  The induction of augmented granulocyte adherence by inflammation. Mediation by a plasma factor.

Authors:  A L Lentnek; A D Schreiber; R R MacGregor
Journal:  J Clin Invest       Date:  1976-04       Impact factor: 14.808

3.  Inhibition of granulocyte adherence by ethanol, prednisone, and aspirin, measured with an assay system.

Authors:  R R MacGregor; P J Spagnuolo; A L Lentnek
Journal:  N Engl J Med       Date:  1974-09-26       Impact factor: 91.245

4.  Factors affecting the adhesiveness of human leucocytes and platelets in vitro.

Authors:  J E GARVIN
Journal:  J Exp Med       Date:  1961-07-01       Impact factor: 14.307

5.  Thrombus formation, hemostasis, adhesiveness of leukocytes and morphological abnormalities in the microcirculation of adjuvant arthritic rats.

Authors:  P Görög; B Kovács
Journal:  Agents Actions       Date:  1976-09

6.  The effect of 3',5'-adenosine monophosphate on granulocyte adhesion.

Authors:  R E Bryant; M C Sutcliffe
Journal:  J Clin Invest       Date:  1974-11       Impact factor: 14.808

7.  Immunoreactants in rheumatoid synovial effusions.

Authors:  N J Zvaifler
Journal:  J Exp Med       Date:  1971-09-01       Impact factor: 14.307
  7 in total
  5 in total

1.  Polymorphonuclear leucocytes in Crohn's disease and ulcerative proctocolitis: association between enhanced adherence to nylon fibre and disease variables.

Authors:  J Cason; C C Ainley; R A Wolstencroft; R P Thompson
Journal:  J Clin Pathol       Date:  1988-03       Impact factor: 3.411

2.  Polymorphonuclear leukocyte function in ulcerative colitis and Crohn's disease.

Authors:  A P Kirk; J Cason; J N Fordham; K A Brown; D H Goddard; E J Holborow; J E Lennard-Jones
Journal:  Dig Dis Sci       Date:  1983-03       Impact factor: 3.199

3.  Polymorphonuclear function in Behçet's syndrome.

Authors:  J N Fordham; P G Davies; A Kirk; H L Currey
Journal:  Ann Rheum Dis       Date:  1982-08       Impact factor: 19.103

4.  Neutrophil adherence in chronic liver disease and fulminant hepatic failure.

Authors:  M Altin; I A Rajkovic; R D Hughes; R Williams
Journal:  Gut       Date:  1983-08       Impact factor: 23.059

5.  The Arthus reaction in rats, a possible test for anti-inflammatory and antiheumatic drugs.

Authors:  L R Pflum; M L Graeme
Journal:  Agents Actions       Date:  1979-06
  5 in total

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