Literature DB >> 6654341

Cystic fibrosis in the Ohio Amish: gene frequency and founder effect.

K W Klinger.   

Abstract

A high incidence of cystic fibrosis (CF), 1/569 live births (0.00176), was found among 10 816 live births in an Ohio Amish isolate. The minimum gene frequency calculated from this incidence was 0.042. In marked contrast, a second Amish isolate was described with no occurrence of CF among 4448 live births. Founder effect is the most probable explanation for the difference in the CF gene frequency between the two communities. Pedigree analysis identified a single ancestral couple born in the 1700s common to all obligate heterozygotes.

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Year:  1983        PMID： 6654341     DOI： 10.1007/BF00286641

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  10 in total

1.  GENETIC STUDIES OF THE AMISH, BACKGROUND AND POTENTIALITIES.

Authors:  V A MCKUSICK; J A HOSTETLER; J A EGELAND
Journal:  Bull Johns Hopkins Hosp       Date:  1964-09

2.  A test for concentration of electrolytes in sweat in cystic fibrosis of the pancreas utilizing pilocarpine by iontophoresis.

Authors:  L E GIBSON; R E COOKE
Journal:  Pediatrics       Date:  1959-03       Impact factor: 7.124

3.  On the Incidence of Cystic Fibrosis of the Pancreas.

Authors:  A G Steinberg; D C Brown
Journal:  Am J Hum Genet       Date:  1960-12       Impact factor: 11.025

4.  A new estimate of the linkage between the genes for colourblindness and haemophilia in man.

Authors:  J B S HALDANE; C A B SMITH
Journal:  Ann Eugen       Date:  1947-10

5.  Heredity of fibrosis of the pancreas; possible mutation rate of the gene.

Authors:  H O GOODMAN; S C REED
Journal:  Am J Hum Genet       Date:  1952-06       Impact factor: 11.025

6.  Factors influencing the frequency of cystic fibrosis in South West Africa.

Authors:  M Super
Journal:  Monogr Paediatr       Date:  1979

7.  Genetic studies on cystic fibrosis in Hawaii.

Authors:  S W Wright; N E Morton
Journal:  Am J Hum Genet       Date:  1968-03       Impact factor: 11.025

8.  The incidence of cystic fibrosis in Caucasian populations.

Authors:  W J Warwick
Journal:  Helv Paediatr Acta       Date:  1978-06

9.  Comments on the possible existence and nature of a heterozygote advantage in cystic fibrosis.

Authors:  C M Anderson; J Allan; P G Johansen
Journal:  Bibl Paediatr       Date:  1967

10.  Cluster of cystic fibrosis cases in a limited area of Brittany (France).

Authors:  E Bois; J Feingold; F Demenais; Y Runavot; M Jehanne; L Toudic
Journal:  Clin Genet       Date:  1978-08       Impact factor: 4.438
  10 in total
  8 in total

1.  Genealogical analysis of cystic fibrosis families and chromosome 7q RFLP haplotypes in the Hutterite Brethren.

Authors:  T M Fujiwara; K Morgan; R H Schwartz; R A Doherty; S R Miller; K Klinger; P Stanislovitis; N Stuart; P C Watkins
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

2.  Evaluating candidate agents of selective pressure for cystic fibrosis.

Authors:  Eric M Poolman; Alison P Galvani
Journal:  J R Soc Interface       Date:  2007-02-22       Impact factor: 4.118

3.  Genetic homogeneity of cystic fibrosis.

Authors:  K Klinger; P Stanislovitis; N Hoffman; P C Watkins; R Schwartz; R Doherty; P Scambler; M Farrall; R Williamson; B Wainwright
Journal:  Nucleic Acids Res       Date:  1986-11-11       Impact factor: 16.971

Review 4.  An appraisal of the application of recombinant DNA techniques to chromosome defects.

Authors:  K P Ellis; K E Davies
Journal:  Biochem J       Date:  1985-02-15       Impact factor: 3.857

5.  Low cancer incidence rates in Ohio Amish.

Authors:  Judith A Westman; Amy K Ferketich; Ross M Kauffman; Steven N MacEachern; J R Wilkins; Patricia P Wilcox; Robert T Pilarski; Rebecca Nagy; Stanley Lemeshow; Albert de la Chapelle; Clara D Bloomfield
Journal:  Cancer Causes Control       Date:  2009-09-25       Impact factor: 2.506

6.  Plasminogen activator inhibitor type 1 gene is located at region q21.3-q22 of chromosome 7 and genetically linked with cystic fibrosis.

Authors:  K W Klinger; R Winqvist; A Riccio; P A Andreasen; R Sartorio; L S Nielsen; N Stuart; P Stanislovitis; P Watkins; R Douglas
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

7.  Care for Amish and Mennonite children with cystic fibrosis: a case series.

Authors:  Jonathan F Henderson; Ran D Anbar
Journal:  BMC Pediatr       Date:  2009-01-15       Impact factor: 2.125

Review 8.  The Changing Epidemiology of Cystic Fibrosis: Incidence, Survival and Impact of the CFTR Gene Discovery.

Authors:  Virginie Scotet; Carine L'Hostis; Claude Férec
Journal:  Genes (Basel)       Date:  2020-05-26       Impact factor: 4.096
  8 in total

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