Literature DB >> 6653851

Frequency of malignant neoplasms in 248 long-term methotrexate-treated psoriatics. A preliminary study.

A Nyfors, H Jensen.   

Abstract

The frequency of malignant neoplasms was studied in 248 psoriatics treated with a single, weekly, oral dose of methotrexate ranging from 5 to 25 mg. The follow-up period ranged from 5 to 14 years with a median of 7 years. The following 10 malignant neoplasms were found: ovarian cancer 3, breast cancer 2, esophageal cancer in 1 male, pancreatic cancer in 1 female, malignant lymphoma in 1 female and 1 male and 1 squamous cell carcinoma of the scrotal skin. As the observed number of malignant neoplasms was considerably smaller than the expected number, it is concluded that methotrexate therapy as used in the treatment of psoriasis does not seem to contribute to the development of malignant neoplasms.

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Year:  1983        PMID： 6653851     DOI： 10.1159/000249793

Source DB:  PubMed          Journal:  Dermatologica        ISSN： 0011-9075


  12 in total

Review 1.  A clinical approach to the use of methotrexate for sarcoidosis.

Authors:  R P Baughman; E E Lower
Journal:  Thorax       Date:  1999-08       Impact factor: 9.139

Review 2.  A risk-benefit assessment of methotrexate in corticosteroid-dependent asthma.

Authors:  T R Shulimzon; R J Shiner
Journal:  Drug Saf       Date:  1996-10       Impact factor: 5.606

Review 3.  Lymphoma in patients with rheumatoid arthritis: what is the evidence of a link with methotrexate?

Authors:  L Georgescu; S A Paget
Journal:  Drug Saf       Date:  1999-06       Impact factor: 5.606

Review 4.  Methotrexate in rheumatoid arthritis: can current knowledge and experience justify its use as a first-line disease-modifying agent?

Authors:  S Tariq; S M Tariq
Journal:  Postgrad Med J       Date:  1993-10       Impact factor: 2.401

Review 5.  Golimumab and malignancies: true or false association?

Authors:  Ines Zidi; Aicha Bouaziz; Wissem Mnif; Aghleb Bartegi; Nidhal Ben Amor
Journal:  Med Oncol       Date:  2010-04-07       Impact factor: 3.064

Review 6.  Psoriasis (chronic plaque).

Authors:  Luigi Naldi; Berthold Rzany
Journal:  BMJ Clin Evid       Date:  2009-01-09

7.  Long-term experience with low dose methotrexate in rheumatoid arthritis.

Authors:  M Tishler; D Caspi; M Yaron
Journal:  Rheumatol Int       Date:  1993       Impact factor: 2.631

8.  Long-term risk of malignancy among patients treated with immunosuppressive agents for ocular inflammation: a critical assessment of the evidence.

Authors:  John H Kempen; Sapna Gangaputra; Ebenezer Daniel; Grace A Levy-Clarke; Robert B Nussenblatt; James T Rosenbaum; Eric B Suhler; Jennifer E Thorne; C Stephen Foster; Douglas A Jabs; Kathy J Helzlsouer
Journal:  Am J Ophthalmol       Date:  2008-06-25       Impact factor: 5.258

9.  Three cases of malignant neoplasm, pneumonitis, and pancytopenia during treatment with low-dose methotrexate.

Authors:  P Trenkwalder; H Eisenlohr; K Prechtel; H Lydtin
Journal:  Clin Investig       Date:  1992-10

10.  A comparison of the malignancy incidence among patients with psoriatic arthritis and patients with rheumatoid arthritis in a large US cohort.

Authors:  Rachael L Gross; Julie S Schwartzman-Morris; Michael Krathen; George Reed; Hong Chang; Katherine C Saunders; Mark C Fisher; Jeffrey D Greenberg; Chaim Putterman; Philip J Mease; Alice B Gottlieb; Joel M Kremer; Anna Broder
Journal:  Arthritis Rheumatol       Date:  2014-06       Impact factor: 10.995
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