Literature DB >> 6653781

Ricin B chain converts a non-cytotoxic antibody-ricin A chain conjugate into a potent and specific cytotoxic agent.

D P McIntosh, D C Edwards, A J Cumber, G D Parnell, C J Dean, W C Ross, J A Forrester.   

Abstract

We report the conversion of a non-cytotoxic antibody-ricin A chain conjugate to one displaying specific cytotoxic effects comparable with that of native ricin, by the addition of ricin B chain as a second stage reagent. The results suggest that this conversion is achieved by the association of the added B chain with the A chain of the conjugate, and not through a primary binding of B chain at the cell surface.

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Year:  1983        PMID： 6653781     DOI： 10.1016/0014-5793(83)80009-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Targeting endothelium and its dynamic caveolae for tissue-specific transcytosis in vivo: a pathway to overcome cell barriers to drug and gene delivery.

Authors:  Deirdre P McIntosh; Xiang-Yang Tan; Phil Oh; Jan E Schnitzer
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-19       Impact factor: 11.205

2.  Blocked and non-blocked ricin immunotoxins against the CD4 antigen exhibit higher cytotoxic potency than a ricin A chain immunotoxin potentiated with ricin B chain or with a ricin B chain immunotoxin.

Authors:  E J Wawrzynczak; G J Watson; A J Cumber; R V Henry; G D Parnell; E P Rieber; P E Thorpe
Journal:  Cancer Immunol Immunother       Date:  1991       Impact factor: 6.968

3.  Cloning and expression of recombinant, functional ricin B chain.

Authors:  M S Chang; D W Russell; J W Uhr; E S Vitetta
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

4.  Comparative studies on kinetics of inhibition of protein synthesis in intact cells by ricin and a conjugate of ricin B-chain with momordin.

Authors:  S Sharma; S K Podder; A A Karande
Journal:  Mol Cell Biochem       Date:  1999-10       Impact factor: 3.396

Review 5.  Enhancement of immunotoxin activity using chemical and biological reagents.

Authors:  M Wu
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

6.  An ineffective monoclonal antibody-ricin A chain conjugate is converted to a tumouricidal agent in vivo by subsequent systemic administration of ricin B chain.

Authors:  S A Eccles; D P McIntosh; H P Purvies; A J Cumber; G D Parnell; J A Forrester; J M Styles; C J Dean
Journal:  Cancer Immunol Immunother       Date:  1987       Impact factor: 6.968

7.  Blocked and not blocked whole-ricin-antibody immunotoxins: intraperitoneal therapy of human tumour xenografted in nude mice.

Authors:  P Brusa; F Pietribiasi; G Bussolati; F Dosio; R Arione; P M Comoglio; M Prat; L Cattel
Journal:  Cancer Immunol Immunother       Date:  1989       Impact factor: 6.968

Review 8.  Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy.

Authors:  Roger Gilabert-Oriol; Alexander Weng; Benedicta von Mallinckrodt; Matthias F Melzig; Hendrik Fuchs; Mayank Thakur
Journal:  Curr Pharm Des       Date:  2014       Impact factor: 3.116
  8 in total

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