Literature DB >> 6653727

Protamine inhibits adenylate cyclase activity: a possible reason for the toxicity of protamine.

Z Kiss, R Zamfirova.   

Abstract

Protamine is an effective inhibitor of the various activated forms of adenylate cyclase of liver plasma membranes. Inhibition of adenylate cyclase may account for its toxic but not its antitumor effects.

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Year:  1983        PMID： 6653727     DOI： 10.1007/BF01990114

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  24 in total

1.  Evidence in intact cells for an involvement of GTP in the activation of adenylate cyclase.

Authors:  G S Johnson; V R Mukku
Journal:  J Biol Chem       Date:  1979-01-10       Impact factor: 5.157

Review 2.  Role of cyclic nucleotides in growth control.

Authors:  I H Pastan; G S Johnson; W B Anderson
Journal:  Annu Rev Biochem       Date:  1975       Impact factor: 23.643

3.  Cyclic guanosine monophosphate and cellular growth.

Authors:  Z Miller; E Lovelace; M Gallo; I Pastan
Journal:  Science       Date:  1975-12-19       Impact factor: 47.728

4.  Cyclic AMP, a nonessential regulator of the cell cycle.

Authors:  P Coffino; J W Gray; G M Tomkins
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205

5.  Simian virus 40 rapidly lowers cAMP levels in mouse cells.

Authors:  A Rein; R A Carchman; G S Johnson; I Pastan
Journal:  Biochem Biophys Res Commun       Date:  1973-06-08       Impact factor: 3.575

6.  Stimulatory effect of ATP on the activity of adenylate cyclase.

Authors:  Z Kiss
Journal:  Biochem Pharmacol       Date:  1980-12-01       Impact factor: 5.858

7.  Involvement of calcium in the inhibition by insulin of the glucagon-stimulated adenylate-cyclase activity.

Authors:  Z Kiss
Journal:  Eur J Biochem       Date:  1979-04

8.  In vivo inhibition of growth of two hormone-dependent mammary tumors by dibutyryl cyclic AMP.

Authors:  Y S Cho-Chung; P M Gullino
Journal:  Science       Date:  1974-01-11       Impact factor: 47.728

9.  Morphological transformation of Chinese hamster cells by dibutyryl adenosine cyclic 3':5'-monophosphate and testosterone.

Authors:  A W Hsie; T T Puck
Journal:  Proc Natl Acad Sci U S A       Date:  1971-02       Impact factor: 11.205

10.  Restoration of contact-inhibited growth to transformed cells by dibutyryl adenosine 3':5'-cyclic monophosphate.

Authors:  J R Sheppard
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205
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  1 in total

Review 1.  Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.

Authors:  P M Henson; R B Johnston
Journal:  J Clin Invest       Date:  1987-03       Impact factor: 14.808
  1 in total

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